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PBMC Donation in UCAR-T Cells

2019-09-23 04:51:50 | BioPortfolio

Summary

Peripheral blood mononuclear cell donation protocol for tumor immunotherapy study of UCAR-T cells

Study Design

Conditions

Peripheral Blood Mononuclear Cell Donation

Intervention

Peripheral blood mononuclear cell apheresis

Location

the First Affiliated Hospital of Nanjing Medical University
Nanjing
Jiangsu
China
210000

Status

Recruiting

Source

The First Affiliated Hospital with Nanjing Medical University

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-09-23T04:51:50-0400

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Medical and Biotech [MESH] Definitions

A form of cutaneous T-cell lymphoma manifested by generalized exfoliative ERYTHRODERMA; PRURITUS; peripheral lymphadenopathy, and abnormal hyperchromatic mononuclear (cerebriform) cells in the skin, LYMPH NODES, and peripheral blood (Sezary cells).

A CCAAT-enhancer-binding protein found in LIVER; ADIPOSE TISSUE; INTESTINES; LUNG; ADRENAL GLANDS; PLACENTA; OVARY and peripheral blood mononuclear cells (LEUKOCYTES, MONONUCLEAR). Experiments with knock-out mice have demonstrated that CCAAT-enhancer binding protein-alpha is essential for the functioning and differentiation of HEPATOCYTES and ADIPOCYTES.

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Mononuclear cells with pronounced phagocytic ability that are distributed extensively in lymphoid and other organs. It includes MACROPHAGES and their precursors; PHAGOCYTES; KUPFFER CELLS; HISTIOCYTES; DENDRITIC CELLS; LANGERHANS CELLS; and MICROGLIA. The term mononuclear phagocyte system has replaced the former reticuloendothelial system, which also included less active phagocytic cells such as fibroblasts and endothelial cells. (From Illustrated Dictionary of Immunology, 2d ed.)

Specialized phagocytic cells of the MONONUCLEAR PHAGOCYTE SYSTEM found on the luminal surface of the hepatic sinusoids. They filter bacteria and small foreign proteins out of the blood, and dispose of worn out red blood cells.

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