Topics

Prospective Analysis of the Th17 Cellular Response in Pemphigus Vulgaris Patients

2019-09-25 06:13:35 | BioPortfolio

Summary

This study will evaluate the pattern of Th17 immune response throughout pemphigus treatment. Skin and serum samples will be taken at the moment of enrollment and at the moment the subject reaches a 75% improvement on disease activity.

Description

Pemphigus is an autoimmune disease characterized by production of autoantibodies against desmogleins 1 and 3, which are part of the epidermis desmosomes. The first line of treatment are corticosteroids with or without the use of adjuvants (e.g. azathioprine, mycophenolate or rituximab). T lymphocytes are responsible for the initiation and maturation of the humoral response and the B cell activation required for the production of autoantibodies. In the last decade, the Th17 immune response has been implicated in the pathogenesis of pemphigus. Recently, the existence of tertiary lymphoid organ-like structures within the skin lesions was suggested. This structures contain T lymphocytes, B lymphocytes and plasma cells; these cells interact and create a local microenvironment for the production of autoantibodies. Most of the T cells in this structures are T helper CD4+ and express IL-21, and half of them produce IL-17.

In this study the investigators aim to evaluate prospectively the Th17 and T regulatory immune response in the lesional skin and serum of active pemphigus subjects that are treated with corticosteroids with or without adjuvants. The investigators will study skin and serum due to the difference of lymphocytes and cytokines in both tissues. The primary hypothesis is: "the subjects who receive corticosteroids with or without adjuvants and who reach a 75% of improvement (measured by the pemphigus disease area index) in comparison to the enrollment visit will have a decrease in Th17 immune response (IL-23).

The investigators will use descriptive statistics, association and correlation test of hypothesis.

Study Design

Conditions

Pemphigus Vulgaris

Location

Hospital General de Mexico
Mexico City
Mexico
06720

Status

Recruiting

Source

Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-09-25T06:13:35-0400

Clinical Trials [292 Associated Clinical Trials listed on BioPortfolio]

Serum IL-21 Levels in Patients With Pemphigus Vulgaris

Pemphigus is severe antigen derived autoimmune bullous skin disorder, the word pemphigus is derived from the Greek word" pemphix " which means blister . Two main clinical variants are know...

Use of KC706 for the Treatment of Pemphigus Vulgaris

The purpose of this study is to determine whether KC706 is effective in the prevention and healing of blisters in patients with pemphigus vulgaris, while the patient remains on stable dose...

Efficacy of Interleukin-2 Gargle in the Treatment of Oral Mucosa Lesion in Pemphigus Vulgaris

This clinical study will test the short-term efficacy of interleukin-2 gargle combined with systemic use of glucocorticoids in the treatment of oral mucosal lesions in mucosal-dominant pem...

Study of Etanercept (Enbrel) in the Treatment of Pemphigus Vulgaris

The purpose of the study is to find out about the effectiveness and the safety of an investigational drug called etanercept (Enbrel) to treat pemphigus vulgaris. Pemphigus vulgaris is a po...

Safety Study of PI-0824 to Treat Pemphigus Vulgaris

The purpose of this study is to determine if the use of PI-0824 in patients with Pemphigus vulgaris is safe.

PubMed Articles [224 Associated PubMed Articles listed on BioPortfolio]

Clinical Markers of Herpes Simplex Virus Infection in Patients with Pemphigus Vulgaris.

Herpes simplex virus (HSV) is known to influence the course of pemphigus vulgaris. Relapse, exacerbation and treatment resistance in patients with pemphigus vulgaris can be due to HSV infection.

Consensus on the treatment of autoimmune bullous dermatoses: pemphigus vulgaris and pemphigus foliaceus - Brazilian Society of Dermatology.

Pemphigus are intraepidermal autoimmune bullous dermatoses that occur with lesions on the skin and / or mucous membranes. The most frequent types are pemphigus vulgaris and pemphigus foliaceus (classi...

Rituximab is an Effective Treatment in Patients with Pemphigus Vulgaris and Demonstrates a Steroid-Sparing Effect.

Corticosteroids (CS) with or without adjuvant immunosuppressant agents are standard treatment for pemphigus vulgaris (PV). The efficacy of adjuvant therapies in minimising steroid-related adverse even...

The involvement of ADAM10 in mucocutaneous pemphigus vulgaris acantholysis depends on the autoantibody profile in each patient.

Acantholysis in pemphigus vulgaris (PV) may be triggered by desmoglein (Dsg) and non-Dsg autoantibodies. The autoantibody profile of each patient results in distinct intracellular signaling patterns.

A case of neonatal pemphigus vulgaris with co-existing BP180 autoantibodies.

A male neonate was born with blisters on the trunk to a 37-year-old primigravid woman with a past medical history of recurrent, painful, topical steroid-responsive oral blisters. The diagnosis of neon...

Medical and Biotech [MESH] Definitions

Separation of the prickle cells of the stratum spinosum of the epidermis, resulting in atrophy of the prickle cell layer. It is seen in diseases such as pemphigus vulgaris (see PEMPHIGUS) and DARIER DISEASE.

A desmosomal cadherin that is an autoantigen in the acquired skin disorder PEMPHIGUS VULGARIS.

An autosomal dominantly inherited skin disorder characterized by recurrent eruptions of vesicles and BULLAE mainly on the neck, axillae, and groin. Mutations in the ATP2C1 gene (encoding the secretory pathway Ca2++/Mn2++ ATPase 1 (SPCA1)) cause this disease. It is clinically and histologically similar to DARIER DISEASE - both have abnormal, unstable DESMOSOMES between KERATINOCYTES and defective CALCIUM-TRANSPORTING ATPASES. It is unrelated to PEMPHIGUS VULGARIS though it closely resembles that disease.

A group of D-related human leukocyte antigens that are polymorphic glycoproteins found on lymphoid cells. They consist of alpha and beta chains and their inheritance differs from that of the DQ and DP antigens; their presence seems to be associated with certain skin diseases like pemphigus vulgaris, dermatitis herpetiformis, and type I diabetes.

A desmosomal cadherin that is an autoantigen in the acquired skin disorder PEMPHIGUS FOLIACEUS.

More From BioPortfolio on "Prospective Analysis of the Th17 Cellular Response in Pemphigus Vulgaris Patients"

Quick Search

Relevant Topics

Wound management
Anything that breaks the skin is a wound because when the skin is broken, there's a risk of germs getting into the body and causing an infection. Follow and track Wound Care News on BioPortfolio: Wound Car...

Autoimmune Disorders
Autoimmune disorders are conditions that occurs when the immune system mistakenly attacks and destroys healthy body tissue. There are more than 80 different types of autoimmune disorders. Normally the immune system's white blood cells help protect ...

Dermatology
Acne Dermatology Eczema Psoriasis Wound Care Dermatology is the medical specialty concerned with the diagnosis and treatment of skin disorders (Oxford Medical Dictionary). As well as studying how the skin works, dermatology covers...


Searches Linking to this Trial