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Anomalies of Dense Platelet Granules

2019-09-25 06:13:39 | BioPortfolio

Summary

The study aims to know the overall prevalence of granular deficits and their breakdown by type (anomaly of number, content or secretion) in a population of patients with hemorrhagic symptomatology after exclusion of other known causes.

This study consists also to evaluate the association between the presence of a deficit in dense granules and (1) the intensity of the hemorrhagic phenotype (hemorrhagic score) (2) the nature of hemorrhages (post-operative, spontaneous, atypical...)

-Evaluate the association between the type of deficit in dense granules and (1) the intensity of the hemorrhagic phenotype (hemorrhagic score) (2) the nature of hemorrhages (post-operative, spontaneous, atypical...)

Description

Patients will be recruited during the exploration visit (v0) or the confirmation/typing visit (v1) according to their follow-up.

- Exploration visit (v0): inclusion of patients without prior platelet exploration, and study of their dense platelet granules.

- Confirmation/typing visit (v1): verification of the persistence of anomalies detected in patients with an abnormality identified during v0 (no later than 6 months after v0) and in patients for whom a dense granules anomaly has already been identified during their standard management prior to the start of the study. Completion of complementary examinations to complement the typing of the granular anomaly and molecular analysis for family cases

Study Design

Conditions

Spontaneous Induced Unexplained Haemorrhagic

Intervention

Haemostasis consultation, Standard management of patients suspected of thrombopathy

Location

Hôpital Necker Enfants Malades - AP-HP
Paris
France
75015

Status

Not yet recruiting

Source

Assistance Publique - Hôpitaux de Paris

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-09-25T06:13:39-0400

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