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Adjunct Phentermine + Topiramate After Bariatric Surgery in 12-24 Year Olds

2019-09-24 05:27:29 | BioPortfolio

Summary

The goal of this pilot study is to establish the feasibility and initial efficacy of the combination of phentermine and topiramate for adolescents and young adults who require additional risk reduction after bariatric surgery. This study will use a randomized, placebo-controlled, double-blinded design to evaluate an adjunctive 12-week intervention of phentermine + topiramate + standard of care vs. placebos + standard of care 6 months after bariatric surgery, among 12 to 24 year olds who don't achieve expected weight loss or who remain severely obese (n=10 total).

Study Design

Conditions

Obesity, Morbid

Intervention

Phentermine, Immediate Release Topiramate, Placebo for Phentermine, Placebo for Immediate Release Topiramate

Location

Children's Hospital Colorado
Aurora
Colorado
United States
80045

Status

Not yet recruiting

Source

Children's Hospital Colorado

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-09-24T05:27:29-0400

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Medical and Biotech [MESH] Definitions

A central nervous system stimulant and sympathomimetic with actions and uses similar to those of DEXTROAMPHETAMINE. It has been used most frequently in the treatment of obesity.

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A hypothalamic tripeptide, enzymatic degradation product of OXYTOCIN, that inhibits the release of MELANOCYTE-STIMULATING HORMONES.

A stable, physiologically active compound formed in vivo from the prostaglandin endoperoxides. It is important in the platelet-release reaction (release of ADP and serotonin).

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