A Pilot Trial of Perinatal Depression Treatment in HIV Infected Women

2019-09-24 05:27:31 | BioPortfolio


This pilot study will evaluate, through quantitative and qualitative methods, whether different treatments for postpartum depression are feasible and acceptable in postpartum HIV infected women on antiretrovirals (ART). The study will take place at several clinics in Lusaka, Zambia.


The standard of care for treating postpartum depression in the US is antidepressants, psychotherapy or both. Little data exist on the best method for treating perinatal depression (PND) in Sub-Saharan Africa. This is a mixed method study including a pilot randomized controlled trial (RCT) of antidepressant medication (ADM) versus interpersonal psychotherapy (IPT) and qualitative semi-structured interviews (SSIs). The study will enroll 150 pregnant HIV infected women over the age of 18 seeking postnatal care and continuing antiretroviral therapy in pregnancy. An additional 20+ eligible women who decline to participate in the RCT will be invited to participate in semi-structured interviews (SSIs) and 20 women enrolled in the RCT will be invited to participate in SSIs.

Each participant will be followed for 24 weeks.

Study Design


Perinatal Depression


Sertraline, Interpersonal therapy


Kamwala District Health Centre


Not yet recruiting


University of North Carolina, Chapel Hill

Results (where available)

View Results


Published on BioPortfolio: 2019-09-24T05:27:31-0400

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