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A Pilot Trial of Perinatal Depression Treatment in HIV Infected Women

2019-09-24 05:27:31 | BioPortfolio

Summary

This pilot study will evaluate, through quantitative and qualitative methods, whether different treatments for postpartum depression are feasible and acceptable in postpartum HIV infected women on antiretrovirals (ART). The study will take place at several clinics in Lusaka, Zambia.

Description

The standard of care for treating postpartum depression in the US is antidepressants, psychotherapy or both. Little data exist on the best method for treating perinatal depression (PND) in Sub-Saharan Africa. This is a mixed method study including a pilot randomized controlled trial (RCT) of antidepressant medication (ADM) versus interpersonal psychotherapy (IPT) and qualitative semi-structured interviews (SSIs). The study will enroll 150 pregnant HIV infected women over the age of 18 seeking postnatal care and continuing antiretroviral therapy in pregnancy. An additional 20+ eligible women who decline to participate in the RCT will be invited to participate in semi-structured interviews (SSIs) and 20 women enrolled in the RCT will be invited to participate in SSIs.

Each participant will be followed for 24 weeks.

Study Design

Conditions

Perinatal Depression

Intervention

Sertraline, Interpersonal therapy

Location

Kamwala District Health Centre
Lusaka
Zambia

Status

Not yet recruiting

Source

University of North Carolina, Chapel Hill

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-09-24T05:27:31-0400

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