Phase II Study of CAPOXIRI+Bevacizumab vs. FOLFOXIRI+Bevacizumab for mCRC

2019-09-26 05:42:45 | BioPortfolio


The objective is to compare the efficacy and safety of CAPOXIRI+BEV therapy versus FOLFOXIRI+BEV therapy as first-line therapy in patients with metastatic colorectal cancer (mCRC).


QUATTRO-II is an open-label, multicenter, randomised, phase II study to investigate the efficacy and safety of CAPOXIRI+BEV versus FOLFOXIRI+BEV in 1st line mCRC.

This study is composed two steps because of confirming of recommended dose (RD) for CAPOXIRI+BEV regimen.

1. Dose finding step (Step1): CAPOXIRI+BEV doses findings were planned by 3+3 cohort design, register up to maximum of 12 cases.

2. Randomised step (Step2): After confirmation of RD regarding CAPOXIRI+BEV, we will move to Step2 to compare the efficacy and safety between FOLFOXIRI+BEV and CAPOXIRI+BEV, register up to 65 cases.

Study Design


Metastatic Colorectal Cancer


Bevacizumab, 5-fluorouracil, Leucovorin calcium, Irinotecan hydrochloride, Oxaliplatin, Capecitabine


Not yet recruiting


Chugai Pharmaceutical

Results (where available)

View Results


Published on BioPortfolio: 2019-09-26T05:42:45-0400

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