Safety, Tolerability and Efficacy of Multiple Intra-articular Injections of LRX712 in Patients With Unilateral Knee OA

2019-09-26 05:42:45 | BioPortfolio


This study will explore the preliminary efficacy of multiple intra-articular injections of LRX712 by evaluating the ability of the drug to restore structural integrity articular cartilage. Efficacy will be evaluated in face of the systemic safety and local tolerability of the investigational drug.


The purpose of this study if to evaluate the safety, tolerability and preliminary efficacy of multiple intra-articular injections of LRX712 in the knee when treating patients with unilateral knee osteoarthritis of mild/moderate severity, in order to support the further clinical development. This study will also allow refinement of the systemic and local pharmacokinetics of LRX712 and the exploration of biomarkers of cartilage breakdown and regeneration in OA patients.

Study Design


Osteoarthritis (OA)


LRX712, Placebo


Novartis Investigative Site
2333 CL


Not yet recruiting



Results (where available)

View Results


Published on BioPortfolio: 2019-09-26T05:42:45-0400

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