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Safety, Tolerability and Efficacy of Multiple Intra-articular Injections of LRX712 in Patients With Unilateral Knee OA

2019-09-26 05:42:45 | BioPortfolio

Summary

This study will explore the preliminary efficacy of multiple intra-articular injections of LRX712 by evaluating the ability of the drug to restore structural integrity articular cartilage. Efficacy will be evaluated in face of the systemic safety and local tolerability of the investigational drug.

Description

The purpose of this study if to evaluate the safety, tolerability and preliminary efficacy of multiple intra-articular injections of LRX712 in the knee when treating patients with unilateral knee osteoarthritis of mild/moderate severity, in order to support the further clinical development. This study will also allow refinement of the systemic and local pharmacokinetics of LRX712 and the exploration of biomarkers of cartilage breakdown and regeneration in OA patients.

Study Design

Conditions

Osteoarthritis (OA)

Intervention

LRX712, Placebo

Location

Novartis Investigative Site
Leiden
Netherlands
2333 CL

Status

Not yet recruiting

Source

Novartis

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-09-26T05:42:45-0400

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