First in Man Clinical Study to Evaluate Safety and Tolerability of an Oncolytic Adenovirus in Prostate Cancer Patients.

2019-09-25 06:13:29 | BioPortfolio


This open label, dose escalating study is a phase I/IIa first in man study designed to evaluate the safety and tolerability of intratumoral administration of a novel oncolytic adenovirus (ORCA-010) in treating diagnosed treatment naïve Patients with localized prostate cancer.


The study is divided into two parts. In Part A of the study, cohorts of subjects will be administered escalating doses of ORCA-010, using the 3+3 design. When the Maximum Tolerated Dose has been determined in Part A, a group of 12 new subjects will be treated in Part B of the study at this dose, with two administrations separated by a 2-week interval.

Study Design


Adenocarcinoma of the Prostate




Jonathan Giddens Medicine Professional Corporation
L6T 4S5


Not yet recruiting


Orca Therapeutics B.V.

Results (where available)

View Results


Published on BioPortfolio: 2019-09-25T06:13:29-0400

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