Safety and Pharmacokinetics Study of MT-3921 in Spinal Cord Injury

2019-09-25 06:13:29 | BioPortfolio


The purpose of this study is to assess the safety, tolerability and pharmacokinetics of MT-3921 in subjects with spinal cord injury.


This is a Phase 1, open-label, single ascending dose study of MT-3921 in subjects with spinal cord injury.

Study Design


Spinal Cord Injury


MT-3921 Low dose, MT-3921 High dose


Barrow Neurological Institute/ St. Joseph's Hospital & Medical Center
United States


Not yet recruiting


Mitsubishi Tanabe Pharma Development America, Inc.

Results (where available)

View Results


Published on BioPortfolio: 2019-09-25T06:13:29-0400

Clinical Trials [9848 Associated Clinical Trials listed on BioPortfolio]

Reducing Anticholinergic Bladder Medication Use in Spinal Cord Injury With Home Neuromodulation

The purpose of this study is to determine the efficacy of home transcutaneous tibial nerve stimulation (TTNS) in spinal cord injury(SCI) and to determine the impact on quality of life usin...

Dose Escalation Study of AST-OPC1 in Spinal Cord Injury

The purpose of this study is to evaluate the safety of 3 sequential escalating doses of AST-OPC1 administered at a single time-point between 14 and 30 days post injury, inclusively, to sub...

A Safety Study for Cethrin (BA-210) in the Treatment of Acute Thoracic and Cervical Spinal Cord Injuries

This trial is a multi-center, open-label, dose-escalation study designed to evaluate the safety, tolerability and pharmacokinetics of Cethrin in two types of spinal cord injury patients: t...

Injured Spinal Cord Pressure Evaluation

About a thousand people a year in the United Kingdom survive a spinal cord injury but are left paralysed or wheelchair-bound. The annual cost of care for spinal cord injury victims is more...

Intrathecal Transplantation of UC-MSC in Patients With Sub-Acute Spinal Cord Injury

This study aim to evaluate the safety and efficacy of intrathecal transplantation of allogeneic umbilical cord derived mesenchymal stem cells (UC-MSC) for treatment of different phrases of...

PubMed Articles [22896 Associated PubMed Articles listed on BioPortfolio]

The effect of TLR4/MyD88 inhibition by salvianolic acid B on neuropathic pain following spinal cord injury in mice.

Spinal cord injury (SCI) is a common type of injury and about one half of the patients affected by SCI will suffer from neuropathic pain within a year after injury. However, the treatment effect of th...

Proprioception: Bottom-up directive for motor recovery after spinal cord injury.

Proprioceptive feedback provides movement-matched sensory information essential for motor control and recovery after spinal cord injury. While it is understood that the fundamental contribution of pro...

Susceptibility of Cervical Spinal Stenosis to Hypoxic Ischemic Cord Injury.

The adult spinal cord is typically resistant to hypoxic ischemic injury (HII) because of collateral blood supply; however, congenital or acquired stenosis may result in baseline maximal vasodilatation...

Employment and job benefits among those with spinal cord dysfunction: A comparison of people with spinal cord injury and multiple sclerosis.

(1) Identify the proportion of participants with spinal cord dysfunction (SCD) reporting each of 10 job benefits and compare the proportions between participants with spinal cord injury (SCI) and mult...

Leuprolide Acetate, a GnRH Agonist, Improves the Neurogenic Bowel in Ovariectomized Rats with Spinal Cord Injury.

Electromyographic studies have shown that external anal sphincter activity is modified in response to distension in animals with spinal cord injury. Gonadotropin-releasing hormone and its agonist leup...

Medical and Biotech [MESH] Definitions

The dose amount of poisonous or toxic substance or dose of ionizing radiation required to kill 50% of the tested population.

Repair of the damaged neuron function after SPINAL CORD INJURY or SPINAL CORD DISEASES.

A treatment schedule in which the total dose of radiation is divided into large doses.

Mice selectively bred for hypersusceptibility to two-stage chemical skin carcinogenesis. They are also hypersusceptible to UV radiation tumorigenesis with single high-dose, but not chronic low-dose, exposures. SENCAR (SENsitive to CARcinogenesis) mice are used in research as an animal model for tumor production.

The highest dose of a biologically active agent given during a chronic study that will not reduce longevity from effects other than carcinogenicity. (from Lewis Dictionary of Toxicology, 1st ed)

More From BioPortfolio on "Safety and Pharmacokinetics Study of MT-3921 in Spinal Cord Injury"

Quick Search

Relevant Topic

Spinal Cord Disorders
The spinal cord is a bundle of nerves that runs down the middle of the back which carry signals back and forth between the body and brain. It is protected by vertebrae, which are the bone disks that make up the spine. An accident that damages the verte...

Searches Linking to this Trial