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The purpose of this study is to assess the safety, tolerability and pharmacokinetics of MT-3921 in subjects with spinal cord injury.
This is a Phase 1, open-label, single ascending dose study of MT-3921 in subjects with spinal cord injury.
Spinal Cord Injury
MT-3921 Low dose, MT-3921 High dose
Barrow Neurological Institute/ St. Joseph's Hospital & Medical Center
Not yet recruiting
Mitsubishi Tanabe Pharma Development America, Inc.
Published on BioPortfolio: 2019-09-25T06:13:29-0400
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(1) Identify the proportion of participants with spinal cord dysfunction (SCD) reporting each of 10 job benefits and compare the proportions between participants with spinal cord injury (SCI) and mult...
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The dose amount of poisonous or toxic substance or dose of ionizing radiation required to kill 50% of the tested population.
Repair of the damaged neuron function after SPINAL CORD INJURY or SPINAL CORD DISEASES.
A treatment schedule in which the total dose of radiation is divided into large doses.
Mice selectively bred for hypersusceptibility to two-stage chemical skin carcinogenesis. They are also hypersusceptible to UV radiation tumorigenesis with single high-dose, but not chronic low-dose, exposures. SENCAR (SENsitive to CARcinogenesis) mice are used in research as an animal model for tumor production.
The highest dose of a biologically active agent given during a chronic study that will not reduce longevity from effects other than carcinogenicity. (from Lewis Dictionary of Toxicology, 1st ed)
Spinal Cord Disorders
The spinal cord is a bundle of nerves that runs down the middle of the back which carry signals back and forth between the body and brain. It is protected by vertebrae, which are the bone disks that make up the spine. An accident that damages the verte...