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Treatment of Chronic Postherpetic Pain With Autologous Fat Grafting - A RCT

2019-09-26 05:42:29 | BioPortfolio

Summary

This randomized clinical trial investigates the possible beneficial effect of autologous fat grafting on postherpetic neuralgia.

Description

Herpes Zoster (HZ), is a condition caused by Varicella-Zoster virus (VZV), The disease is caused by reactivation of a latent VZV-infection in the sensory ganglia.

Clinically the condition is characterized by a painful, unilateral, vesicular rash. Pain is the most prominent symptom in around 90% of patients. In 10% of patients, this pain remains and becomes chronic.

Post-herpetic neuralgia is a chronic pain syndrome that occurs after the dermal manifestation disappears. Treatment is complex and mainly topical or systemic. For many patients, this is not sufficient and they live with constant pain.

Autologous fat grafting has shown promise in treating several different painful conditions such as post-mastectomy pain syndrome, painful scars, etc. Our previous pilot study (NCT03584061) investigating the effect of autologous fat grafting on PHN, showed a marked reduction in pain with half of the patients being pain-free after the procedure.

The aim of this study is to test the hypothesis that autologous fat grafting is more effective than a sham operation in treating PHN.

Study Design

Conditions

Postherpetic Neuralgia

Intervention

Autologous Fat Grafting / Fat Transplant

Location

Odense University Hospital
Odense
Funen
Denmark
5000

Status

Recruiting

Source

Odense University Hospital

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-09-26T05:42:29-0400

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Gabapentin and pregabalin are treatments for some types of neuropathic pain, including postherpetic neuralgia (PHN). However, these treatments usually need to be taken 3 times a day for e...

Safety and Efficacy of Gabapentin in Postherpetic Neuralgia

Gabapentin and pregabalin are treatments for some types of neuropathic pain, including postherpetic neuralgia (PHN). However, these treatments usually need to be taken 3 times a day for ef...

Treatment of Chronic Postherpetic Pain With Fat Grafting

This study evaluates the possible beneficial effect of fat grafting for post herpetic neuralgia.

Safety and Efficacy Study of KAI-1678 to Treat Pain in Subjects With Postherpetic Neuralgia

The purpose of this study is to determine whether KAI-1678 is effective in the treatment of postherpetic neuralgia pain

Safety and Preliminary Efficacy of MK0759 in Postherpetic Neuralgia (PHN)

The purpose of this study is to test the safety and effect of MK0759 in relieving neuropathic pain as experienced by patients with postherpetic neuralgia (PHN).

PubMed Articles [2347 Associated PubMed Articles listed on BioPortfolio]

Analysis of the Risk Factors for Postherpetic Neuralgia.

Postherpetic neuralgia is the most common complication of herpes zoster, affecting 30% of patients. It seriously affects the quality of life of patients and the curative effect of treatment is limited...

Treatment Patterns and Medication Use in Patients with Postherpetic Neuralgia.

Postherpetic neuralgia (PHN) is a chronic, painful condition characterized by persistent pain following resolution of a herpes zoster (HZ) infection. Epidemiologic data demonstrate that the risks for ...

Treatment of chronic post-herpetic neuralgia with autologous fat grafts: a first-in-the-world case report.

A 60-year-old woman suffering from severe chronic post-herpetic neuralgia (PHN) was treated with simple autologous fat grafting to the affected area of skin. Post-operatively, she reported a great imp...

Efficacy of gabapentin for the prevention of postherpetic neuralgia in patients with acute herpes zoster: A double blind, randomized controlled trial.

Postherpetic neuralgia (PHN) is the most common complication of herpes zoster (HZ). Previous trials have reported that gabapentin can relieve chronic neuropathic pain, but its effect on prevention of ...

Clinical Study of Ultrasound-Guided Methylene Blue Thoracic Paravertebral Nerve Block for the Treatment of Postherpetic Neuralgia.

The aim of this study was to investigate the effect of ultrasound-guided methylene blue (MB) thoracic paravertebral nerve block (TPVB) on the treatment of postherpetic neuralgia (PHN).

Medical and Biotech [MESH] Definitions

An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake.

Pain in nerves, frequently involving facial SKIN, resulting from the activation the latent varicella-zoster virus (HERPESVIRUS 3, HUMAN). The two forms of the condition preceding the pain are HERPES ZOSTER OTICUS; and HERPES ZOSTER OPHTHALMICUS. Following the healing of the rashes and blisters, the pain sometimes persists.

Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.

Providers of tissues for transplant to non-related individuals.

Transplant comprised of an individual's own tissue, transferred from one part of the body to another.

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