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Early Feasibility EXperience of Posterior Leaflet RestOration to REduce Mitral Regurgitation

2019-09-26 05:42:39 | BioPortfolio

Summary

Early feasibility study, single-arm registry design

Description

First-In-Human

Study Design

Conditions

Mitral Regurgitation

Status

Not yet recruiting

Source

Polares Medical SA

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-09-26T05:42:39-0400

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Medical and Biotech [MESH] Definitions

Backflow of blood from the LEFT VENTRICLE into the LEFT ATRIUM due to imperfect closure of the MITRAL VALVE. This can lead to mitral valve regurgitation.

Abnormal protrusion or billowing of one or both of the leaflets of MITRAL VALVE into the LEFT ATRIUM during SYSTOLE. This allows the backflow of blood into left atrium leading to MITRAL VALVE INSUFFICIENCY; SYSTOLIC MURMURS; or CARDIAC ARRHYTHMIA.

Narrowing of the passage through the MITRAL VALVE due to FIBROSIS, and CALCINOSIS in the leaflets and chordal areas. This elevates the left atrial pressure which, in turn, raises pulmonary venous and capillary pressure leading to bouts of DYSPNEA and TACHYCARDIA during physical exertion. RHEUMATIC FEVER is its primary cause.

A type of heart valve surgery that involves the repair, replacement, or reconstruction of the annulus of the MITRAL VALVE. It includes shortening the circumference of the annulus to improve valve closing capacity and reinforcing the annulus as a step in more complex valve repairs.

Regurgitation and re-chewing of previously swallowed food in RUMINANTS.

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