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Evaluation of Increased Absorption of a Curcumin Emulsion (BIOCURC) in Healthy Volunteers

2019-10-01 07:55:14 | BioPortfolio

Summary

This study is intended to evaluate the comparative effects of direct analysis of serum samples versus pre-treatment with enzymatic hydrolysis in split samples obtained from dosing with a highly absorbed curcumin emulsion product that is commercially available as BIOCURC.

Description

When curcumin is absorbed by the body, it is primarily found in the bloodstream as curcumin glucuronide (C-gluc) and curcumin sulfate (C-SO4) metabolites. Traditionally bioavailability studies have performed an enzymatic hydrolysis pre-treatment of serum samples with both a glucuronidase and a sulfatase enzyme in order to produce free curcumin for analysis via HPLC. In subsequent years, standards have become available for the metabolites (C-gluc & C-SO4) that make it possible to determine these compound levels directly in serum samples using HPLC-MS-MS. Initial pilot work had indicated that enzymatic hydrolysis was producing falsely elevated results for bioavailability. We wanted to evaluate this in a more formal setting.

Study Design

Conditions

Bioavailability

Intervention

95% Curcuminoid Powder, BIOCURC

Location

QPS Bio-Kinetic
Springfield
Missouri
United States
65802

Status

Completed

Source

ESM Technologies, LLC

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-10-01T07:55:14-0400

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