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Sacubitril/Valsartan in Left Ventricular Assist Device Recipients

2019-10-01 07:55:15 | BioPortfolio

Summary

The primary objective of this study is to assess the safety and tolerability of sacubitril/valsartan compared with enalapril in patients that have been recently implanted with the HM3 (events of special interest - all cause death, right ventricular failure, bleeding events, deterioration in renal function, hyperkalemia, hypotension).

Study Design

Conditions

Heart Failure

Intervention

Sacubitril-Valsartan, Enalapril

Status

Not yet recruiting

Source

University of Zagreb

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-10-01T07:55:15-0400

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Medical and Biotech [MESH] Definitions

Heart Failure

A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.

Enalaprilat

The active metabolite of ENALAPRIL and a potent intravenously administered angiotensin-converting enzyme inhibitor. It is an effective agent for the treatment of essential hypertension and has beneficial hemodynamic effects in heart failure. The drug produces renal vasodilation with an increase in sodium excretion.

Cardiomegaly

Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.

Amlodipine, Valsartan Drug Combination

A pharmaceutical preparation of amlodipine and valsartan that is used for the treatment of HYPERTENSION.

Heart Failure, Diastolic

Heart failure caused by abnormal myocardial relaxation during DIASTOLE leading to defective cardiac filling.