Comparison of Lower-risk MDS Patients With and Without Improvements in Fatigue Following Blood Transfusion Therapy

2019-10-01 07:55:17 | BioPortfolio


At present, it is unclear why some myelodysplastic patients (MDS) receiving blood transfusion therapy exhibit an increase in Hemoglobin (Hb) without a concurrent improvement in fatigue. Research is thus required to elucidate on why fatigue persists in some MDS patients in order to devise strategies to alleviate fatigue in "non-responders" to blood transfusion.


One hypothesis is that patients who exhibited persistent fatigue following a blood- transfusion- induced increase in Hb have an impaired ability to utilize oxygen at the peripheral level. This could be the consequence of impairments in vascular function, mediated by endothelial dysfunction as a result of transfusion-induced iron-overload and oxidative stress associated with the disease. Taking the current gaps in knowledge pertaining to MDS-related fatigue into account, the objective of this study is to improve understanding on the aetiology fatigue in MDS patients. To achieve this aim, the study will measure a comprehensive group of patient-reported and disease-related outcomes: i) prior to blood transfusion therapy when Hb levels are low and; ii) following blood transfusion therapy, when Hb levels have been increased. Results from the post-transfusion tests will be analyzed to determine which participants remain fatigued despite an increase in Hb, and which participants shown an improvement in fatigue.

Study Design


Myelodysplatic Syndromes


Physiological tests to measure fatigue level


Institut de Cancérologie Lucien Neuwirth


Not yet recruiting


Institut de Cancérologie de la Loire

Results (where available)

View Results


Published on BioPortfolio: 2019-10-01T07:55:17-0400

Clinical Trials [1885 Associated Clinical Trials listed on BioPortfolio]

Yan Nian Jiu Zhuan Fa Improve Chronic Fatigue Syndromes

This study is to disclose the mechanism of characteristic Tao yin exercises regulate Chronic Fatigue Syndromes based on Brain-Gut Axis.Explore the clinical manifestation of Chronic Fatigue...

Cause and Consequence of Neural Fatigue

While the scientific community understands quite well why muscles ache after prolonged exercise, the origins of mental fatigue remain totally mysterious. Existing theories remain at a psyc...

Patient-Centered Assessment of Symptoms and Outcomes

Background: The cause of fatigue is not well understood. It can be felt differently by different people. Some people think there are different types of fatigue, with different causes. Res...

Evaluation and Diagnosis of People With Pain and Fatigue Syndromes

This study will examine people who have pain or fatigue symptoms with a known or unknown diagnosis to determine eligibility for other research studies. No treatment is offered under this p...

Noradrenergic and Stress-Related Etiologies of Chronic Fatigue Syndrome

The objective of this study is to measure sympathetic nervous system function and stress responses in patients with clinically documented and self-reported chronic fatigue that is worsened...

PubMed Articles [16524 Associated PubMed Articles listed on BioPortfolio]

Effects of fatigue on teams and their role in 24/7 operations.

In 24/7 operations, fatigue from extended work hours and shift work is ubiquitous. Fatigue is a significant threat to performance, productivity, safety, and well-being, and strategies for managing fat...

The Effect of Fatigue on Working Memory and Auditory Perceptual Abilities in Trained Musicians.

Purpose Many perceptual processing processes, such as cognition, vision, sensation, and audition, are affected due to fatigue. Musicians are prone to fatigue because of long working hours and demandin...

Minimally important difference of the fatigue severity scale and modified fatigue impact scale in people with multiple sclerosis.

Fatigue is a common and debilitating symptom of Multiple Sclerosis (MS); however, it is unknown what constitutes a clinically significant change in fatigue. Establishing the minimally important differ...

Muscle performance and fatigue in compensated chronic liver disease.

A common and debilitating symptom in patients with chronic liver disease is fatigue (CLD). Muscle dysfunction has been suggested to be a key mechanism of fatigue in CLD. We aimed to evaluate fatigue ...

Impaired sarcoplasmic reticulum Ca release is the major cause of fatigue-induced force loss in intact single fibres from human intercostal muscle.

Changes in intramuscular Ca handling contribute to development of fatigue and disease-related loss of muscle mass and function. To date, no data on human intact living muscle fibres have been describe...

Medical and Biotech [MESH] Definitions

Standardized tests designed to measure abilities, as in intelligence, aptitude, and achievement tests, or to evaluate personality traits.

A state arrived at through prolonged and strong contraction of a muscle. Studies in athletes during prolonged submaximal exercise have shown that muscle fatigue increases in almost direct proportion to the rate of muscle glycogen depletion. Muscle fatigue in short-term maximal exercise is associated with oxygen lack and an increased level of blood and muscle lactic acid, and an accompanying increase in hydrogen-ion concentration in the exercised muscle.

Standardized tests that measure the present general ability or aptitude for intellectual performance.

Sensitive tests to measure certain antigens, antibodies, or viruses, using their ability to agglutinate certain erythrocytes. (From Stedman, 26th ed)

Tests or bioassays that measure the skin sensitization potential of various chemicals.

More From BioPortfolio on "Comparison of Lower-risk MDS Patients With and Without Improvements in Fatigue Following Blood Transfusion Therapy"

Quick Search

Relevant Topics

Blood is a specialized bodily fluid that delivers necessary substances to the body's cells (in animals) – such as nutrients and oxygen – and transports waste products away from those same cells.  In vertebrates, it is composed of blo...

Vascular relates to blood vessels (Oxford Medical Dictionary) and can be used to describe the supply of blood, a disease affecting the blood vessels or molecules associated with these structures. For example, <!--LGfEGNT2Lhm-->atherosclerosis ...

Stress is caused by your perception of situations around you and then the reaction of your body to them. The automatic stress response to unexpected events is known as 'fight or flight'. Discovered by Walter Cannon in 1932, it is the release of h...

Searches Linking to this Trial