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Sixty patients will be randomly assigned to receive either a Smith & Nephew Journey II or Zimmer NexGen LPS-Flex knee implant. Patients will undergo biomechanics testing while they complete sit-to-stand, stand-to-sit, lateral step down, level walking, and single leg balance tasks up to 1 month before surgery, and 6 and 12 months after surgery. They will also undergo MRI imaging up to 1 month before surgery and 12 months after surgery to assess muscle quality. A secondary outcome will also be to analyze the immunological response in the patients who received femoral components made of oxidized zirconium versus contemporary components made of cobalt chrome. Fifteen healthy controls will also participate in the study and will undergo the biomechanical, MRI and blood draws at a single visit.
Zimmer NexGen LPS-Flex, Smith & Nephew Journey II
The Ottawa Hospital
Ottawa Hospital Research Institute
Published on BioPortfolio: 2019-10-01T07:54:59-0400
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