Examination of Immunosuppression Adjustment Impact on Kidney Function in Liver Transplant

2019-10-01 07:55:06 | BioPortfolio


This is a study to help understand how well new combinations of immunosuppressive medications (medications that weaken your immune system to prevent your body from rejecting the transplanted liver) work compared to standard immunosuppressive medications after your liver transplant. Also the study will assess how safe the new combination of immunosuppressive medicines are and if there are any changes in how your kidneys work after taking these medicines.


A single center, open label, randomized, prospective, pilot study of induction and maintenance immunosuppression in adult subjects >18 years undergoing orthotopic liver transplantation (OLT) with Basiliximab, delayed dose tacrolimus plus mycophenolate mofetil and standard of care (SOC) corticosteroids (Group 1) versus basiliximab, delayed dose tacrolimus plus mycophenolate mofetil, SOC corticosteroids, with addition of delayed maintenance Everolimus at one month post OLT with subsequent mycophenolate mofetil minimization (Group 2) versus standard dose tacrolimus plus mycophenolate mofetil plus SOC corticosteroids (Group 3; control) with concomitant renal dysfunction prior to OLT.

Study Design


Asses Immunosuppression Modulation on Renal Recovery Post LT


Basiliximab 20 MG


UCLA Medical Center
Los Angeles
United States


Not yet recruiting


University of California, Los Angeles

Results (where available)

View Results


Published on BioPortfolio: 2019-10-01T07:55:06-0400

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