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The study aims to evaluate the feasibility of a repetitive transcranial magnetic simulation (rTMS) protocol developed for managing pain and other related symptoms associated with oxaliplatin-induced peripheral neuropathy in cancer patients.
A total of 60 cancer patients with oxaliplatin-induced peripheral neuropathy (OXAIPN) will be recruited. After randomization, the experimental group (n = 30) will receive high-frequency rTMS, while the control group (n = 30) will receive sham rTMS. The rTMS will be delivered over M1 (hand representation) of dual hemispheres with 10 trains of 10 Hz pulses for 10 seconds, with a total of 1,000 pulses per hemisphere. The rTMS intensity will be set as 80% resting motor threshold and the interval between each train of pulses will be set as 50 seconds. The rTMS will be delivered as daily session for five consecutive days, followed by two fortnightly maintenance sessions during the follow-up period after the completion of five daily sessions. The rTMS will be delivered by designated physical therapists using "figure-of-8" shaped coil connected to an electromagnetic stimulator in the rehabilitation therapy room of three hospitals in the Chinese mainland.
The research outcomes are feasibility (recruitment, retention rate, guess of group allocation, and appropriateness of clinical outcome measures), acceptability (patients' and providers' satisfaction with rTMS, patients' actual use of rTMS, patients' willingness of using rTMS in the future, and patients perceived effectiveness of rTMS), safety, and trend of improvement in pain, other related symptoms, and quality of life by rTMS in cancer patients with OXAIPN. Evaluation of the study process will be performed with qualitative semi-structured interview.
Oxaliplatin-induced Peripheral Neuropathy
Real repetitive transcranial magnetic stimulation, Sham repetitive transcranial magnetic stimulation
Not yet recruiting
The Hong Kong Polytechnic University
Published on BioPortfolio: 2019-10-03T07:54:49-0400
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