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Each year, approximately 15,000 people in the United Kingdom experience sudden loss of hearing. Of those who present to the NHS, the cause is unknown in most cases despite investigation, and these cases are termed idiopathic 'sudden onset sensorineural hearing loss' (SSNHL). Treatment options for idiopathic SSNHL mainly include steroid treatments and their efficacy is not well known.
There are a number of new treatments being developed for SSNHL based upon recent discoveries regarding factors causing the condition. These treatments require rigorous testing in clinical trials before they can become available for clinical use. To allow for such trials to be run there is an urgent need for information on patient numbers and characteristics, geographical distribution, patient and treatment pathways, as well as outcomes. There is an urgent need to understand this patient population to help develop new treatments.
The investigators will record routinely collected information of patients presenting with SSNHL (including: patient characteristics, treatment received, hearing levels). This will take place at 97 National Health Services (NHS) sites across the country with Ear, Nose, and Throat (ENT) and Audiology services. 20 of these sites will also collect quality of life information via questionnaires.
Once the data has been collected, it will be analysed to:
1. Establish the patient pathway for patients presenting with SSNHL in the NHS
2. Develop a tool that will help predict recovery for patients with SSNHL.
3. Establish the impact of SSNHL on people's quality of life.
Brief background Currently there is insufficient evidence about the patient pathway and hearing outcomes of patients presenting with SSNHL in the NHS.
Based on recent discoveries in the molecular mechanisms that lead to SSNHL, new therapeutics are being developed that are ready for trialing.
To allow for these trials to be run effectively and reliably within the NHS, information on where and when patients with idiopathic SSNHL present and how they fare needs to be known.
1. To map the patient pathway and identify the characteristics of adult patients presenting to NHS ENT and hearing services with SSNHL.
2. To develop a prediction model to predict recovery for patients with SSNHL.
3. Establish the impact of idiopathic SSNHL on patients' quality of life
Methods Study design: National multicentre prospective observational cohort study across 97 trusts.
Inclusion/Exclusion criteria: Adult patients with idiopathic SSNHL presenting to the NHS Data collection: Using REDCap, patient demographics, geographical distribution, treatment pathways and outcomes will be recorded. A selection of these sites (n=20) will collect patient quality of life data.
Analysis: A multivariable prognostic model will be created to predict recovery for patients with SSNHL.
Sensory Hearing Loss
Quality of life questionnaire
Enrolling by invitation
University College, London
Published on BioPortfolio: 2019-10-03T07:54:39-0400
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