Glasdegib for Chronic Graft-Versus-Host Disease

2019-10-07 08:56:48 | BioPortfolio


This phase I/II trial studies whether glasdegib is helpful in treating sclerosis associated with chronic graft-versus-host disease. It will also investigate the safety of glasdegib in treating patients with chronic graft-versus-host disease.


OUTLINE: This is a phase I/II study.

Patients receive glasdegib orally (PO) once daily (QD) on days 1-28. Cycles repeat every 28 days for up to 24 months in the absence of disease progression or unacceptable toxicity.

Study Design


Chronic Graft Versus Host Disease




Duke University Medical Center
North Carolina
United States


Not yet recruiting


Fred Hutchinson Cancer Research Center

Results (where available)

View Results


Published on BioPortfolio: 2019-10-07T08:56:48-0400

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PubMed Articles [26566 Associated PubMed Articles listed on BioPortfolio]

Histological and clinical cross-sectional study of chronic hair loss in patients with cutaneous chronic graft-versus-host disease.

While scalp alopecia represents a distinctive feature of chronic graft-versus-host disease (cGVHD), little is known about the clinical and histological presentation of hair loss.

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IL-17A Contributes to Lung Fibrosis in a Model of Chronic Pulmonary Graft-versus-host Disease.

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Coping and modifiable psychosocial factors are associated with mood and quality of life in patients with chronic graft-versus-host-disease (GVHD).

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Medical and Biotech [MESH] Definitions

An immunological attack mounted by a graft against the host because of tissue incompatibility when immunologically competent cells are transplanted to an immunologically incompetent host; the resulting clinical picture is that of GRAFT VS HOST DISEASE.

The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.

The immune responses of a host to a graft. A specific response is GRAFT REJECTION.

The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.

Manipulation of the host's immune system in treatment of disease. It includes both active and passive immunization as well as immunosuppressive therapy to prevent graft rejection.

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