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The Use of A Prebiotic to Promote a Healthy Gut Microbiome in Pediatric Stem Cell Transplant Recipients

2019-10-07 08:56:48 | BioPortfolio

Summary

Children enrolled in the study will receive either the prebiotic inulin or a placebo for 21 days during the study period. They will start taking the product seven days before transplant starts until 14 days after transplant. Stool will be collected twice weekly until thirty days after transplant or discharge, whichever occurs first. Stool samples will be sampled for metagenomic sequencing to identify the diversity of bacteria within the stool. They will also be analyzed for amount of short-chain fatty acid content (a breakdown product of inulin) as well as for presence of genes that confer antibiotic resistance. From 30 days after transplant until 100 days after transplant, two stool samples will be collected at regularly scheduled follow up appointments (near day 60 and day 100). No product (inulin or placebo) will be given during this time frame. The study period ends 100 days after transplant.

Study Design

Conditions

Microbial Colonization

Intervention

Prebiotics, Placebos

Status

Not yet recruiting

Source

Ann & Robert H Lurie Children's Hospital of Chicago

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-10-07T08:56:48-0400

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