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DKK3 for Prognosis and Monitoring of GFR Loss in Heart Failure

2019-10-07 08:56:52 | BioPortfolio

Summary

The individual course of chronic kidney disease (CKD) may vary, and improved methods for identifying which patients will experience estimated glomerular filtration rate (eGFR) loss are needed. Recently, urinary dickkopf-3 (DKK3) has been proposed to predict eGFR loss in patients with CKD, independent of presence of albuminuria. We sought to examine the association between DKK3 and loss of eGFR in patients with heart failure (HF). We hypothesized that changes in DKK3 under treatment may be helpful to monitor individual kidney disease course.

Description

The individual course of chronic kidney disease (CKD) may vary, and improved methods for identifying which patients will experience estimated glomerular filtration rate (eGFR) loss are needed. Recently, urinary dickkopf-3 (DKK3) has been identified as a stress-induced, renal tubular epithelia-derived, secreted glycoprotein that induces tubulointerstitial fibrosis. Urinary DKK3 has been found to predict eGFR loss in patients with CKD, independent of presence of albuminuria. We sought to examine the association between DKK3 and loss of eGFR in patients with heart failure (HF). Also, we hypothesized that changes in DKK3 under treatment may be helpful to monitor individual kidney disease course.

Study Design

Conditions

Heart Failure

Intervention

No intervention

Location

University Clinic Giessen and Marburg - Campus Giessen
Giessen
Hessen
Germany
35392

Status

Recruiting

Source

University of Giessen

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-10-07T08:56:52-0400

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