DKK3 for Prognosis and Monitoring of GFR Loss in Heart Failure
Summary
The individual course of chronic kidney disease (CKD) may vary, and improved methods for identifying which patients will experience estimated glomerular filtration rate (eGFR) loss are needed. Recently, urinary dickkopf-3 (DKK3) has been proposed to predict eGFR loss in patients with CKD, independent of presence of albuminuria. We sought to examine the association between DKK3 and loss of eGFR in patients with heart failure (HF). We hypothesized that changes in DKK3 under treatment may be helpful to monitor individual kidney disease course.
Description
The individual course of chronic kidney disease (CKD) may vary, and improved methods for identifying which patients will experience estimated glomerular filtration rate (eGFR) loss are needed. Recently, urinary dickkopf-3 (DKK3) has been identified as a stress-induced, renal tubular epithelia-derived, secreted glycoprotein that induces tubulointerstitial fibrosis. Urinary DKK3 has been found to predict eGFR loss in patients with CKD, independent of presence of albuminuria. We sought to examine the association between DKK3 and loss of eGFR in patients with heart failure (HF). Also, we hypothesized that changes in DKK3 under treatment may be helpful to monitor individual kidney disease course.
Study Design
Conditions
Heart Failure
Intervention
No intervention
Location
University Clinic Giessen and Marburg - Campus Giessen
Giessen
Hessen
Germany
35392
Status
Recruiting
Source
University of Giessen
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT04111094
- ClinicalTrials.gov processed this data on October 04, 2019
Published on BioPortfolio: 2019-10-07T08:56:52-0400
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Medical and Biotech [MESH] Definitions
Heart Failure
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
Cardiomegaly
Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
Heart Failure, Diastolic
Heart failure caused by abnormal myocardial relaxation during DIASTOLE leading to defective cardiac filling.
Heart Failure, Systolic
Heart failure caused by abnormal myocardial contraction during SYSTOLE leading to defective cardiac emptying.
Cardiotonic Agents
Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).
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