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The overall objective of this project is to identify clinical and genetic risk factors for Atypical Femur Fractures (AFFs) in Anti-resorptive therapy (ART) users by conducting a case control study of 330 cases of AFFs and 660 controls without AFFs matched for age, sex, race and duration of ART.
Antiresorptive therapy (ART) drugs are effective osteoporosis treatment and help decrease osteoporosis-related fractures. However, their long-term use has been associated with rare but serious atypical femur fractures (AFFs). Fear of these side effects has caused a substantial decline in the use of these effective drugs and rising fracture rates. The investigators propose to compare 330 cases of people with AFFs to 660 matched controls to explore similarities and differences in (1) clinical findings, such as type of ART and length of use, prior fracture, bone density, femur geometry, etc., and (2) genetic variants, and then (3) to validate the top few genetic variants to see if they are indeed present in an additional group of 100 AFF patients and not present in 100 control subjects. This study will determine clinical and genetic risk factors for these debilitating atypical fractures such that at-risk patients in the future can be treated differently to avoid them.
Atypical Femur Fracture
Adachi Medical Centre
University Health Network, Toronto
Published on BioPortfolio: 2019-10-07T08:56:54-0400
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Implantable fracture fixation devices attached to bone fragments with screws to bridge the fracture gap and shield the fracture site from stress as bone heals. (UMDNS, 1999)
The constricted portion of the thigh bone between the femur head and the trochanters.
Fracture in the proximal half of the shaft of the ulna, with dislocation of the head of the radius.
The use of metallic devices inserted into or through bone to hold a fracture in a set position and alignment while it heals.
Ligament that connects the fovea of the FEMUR HEAD and the ACETABULUM notch in the HIP JOINT.
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