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Penehyclidine and Postoperative Nausea and Vomiting After Bimaxillary Surgery

2019-10-08 08:47:35 | BioPortfolio

Summary

Postoperative nausea and vomiting (PONV) are common complications after surgery. Patients undergoing orthognathic surgery were reported to have a high risk of PONV, especially those undergoing bimaxillary surgery. Activation of cholinergic system plays an important role in the development of PONV. Penehyclidine is an anticholinergic agent which selectively block M1 and M3 receptors and is commonly used to decrease oral secretion. The purpose of this retrospective cohort study is to investigate whether use of penehyclidine is associated with a reduced risk of PONV in patients undergoing bimaxillary surgery.

Description

Postoperative nausea and vomiting (PONV) are one of the most frequent complications after surgery. It is related to patients' dissatisfaction after anesthesia and surgery. Orthognathic surgery is widely performed for the correction of dentofacial deformities. PONV is a common postoperative complication after orthognathic surgery. Despite of improved anti-emetic therapies, patients undergoing orthognathic surgery are reported to have a high incidence of PONV, especially those after bimaxillary surgery.

It is known that activation of central cholinergic system plays an important role in the development of PONV. Anticholinergics such as scopolamine can block muscarinic receptors in the cerebral cortex and produce anti-emetic effects. Penehyclidine is a new anticholinergic agent which selectively block M1 and M3 receptors. It has fewer adverse effects compared with other anticholinergics. The purpose of this retrospective cohort study is to investigate whether use of penehyclidine is associated with a reduce risk of PONV in patients undergoing bimaxillary surgery.

Study Design

Conditions

Penehyclidine

Intervention

Penehyclidine hydrochloride, No penehyclidine hydrochloride

Location

Peking University Hospital of Stomatology
Beijing
Beijing
China
100081

Status

Not yet recruiting

Source

Peking University First Hospital

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-10-08T08:47:35-0400

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