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CompARE: Escalating Treatment of Intermediate and High-risk Oropharyngeal Cancer (OPC)

2019-10-10 09:39:39 | BioPortfolio

Summary

CompARE is a multicentre, phase III open-label randomised controlled trial using an adaptive, Multi-Arm, Multi-Stage (MAMS) design.

Description

The CompARE Trial examines alternative regimens for escalating treatment of intermediate and high-risk oropharyngeal cancer in an adult patient population. The aim is to assess whether escalated radiotherapy, adding surgery or immunotherapy will improve overall survival and quality of life in these patients.

Study Design

Conditions

Oropharyngeal Cancer

Intervention

Cisplatin, Durvalumab, Radiotherapy, Dose-escalated radiotherapy

Location

Royal Devon and Exeter Hospital
Exeter
Devon
United Kingdom
EX2 5DW

Status

Recruiting

Source

University of Birmingham

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-10-10T09:39:39-0400

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Medical and Biotech [MESH] Definitions

Radiotherapy where there is improved dose homogeneity within the tumor and reduced dosage to uninvolved structures. The precise shaping of dose distribution is achieved via the use of computer-controlled multileaf collimators.

Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. Adjuvant radiotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.

CONFORMAL RADIOTHERAPY that combines several intensity-modulated beams to provide improved dose homogeneity and highly conformal dose distributions.

The total amount of radiation absorbed by tissues as a result of radiotherapy.

Radiotherapy where cytotoxic radionuclides are linked to antibodies in order to deliver toxins directly to tumor targets. Therapy with targeted radiation rather than antibody-targeted toxins (IMMUNOTOXINS) has the advantage that adjacent tumor cells, which lack the appropriate antigenic determinants, can be destroyed by radiation cross-fire. Radioimmunotherapy is sometimes called targeted radiotherapy, but this latter term can also refer to radionuclides linked to non-immune molecules (see RADIOTHERAPY).

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