CompARE: Escalating Treatment of Intermediate and High-risk Oropharyngeal Cancer (OPC)
Summary
CompARE is a multicentre, phase III open-label randomised controlled trial using an adaptive, Multi-Arm, Multi-Stage (MAMS) design.
Description
The CompARE Trial examines alternative regimens for escalating treatment of intermediate and high-risk oropharyngeal cancer in an adult patient population. The aim is to assess whether escalated radiotherapy, adding surgery or immunotherapy will improve overall survival and quality of life in these patients.
Study Design
Conditions
Oropharyngeal Cancer
Intervention
Cisplatin, Durvalumab, Radiotherapy, Dose-escalated radiotherapy
Location
Royal Devon and Exeter Hospital
Exeter
Devon
United Kingdom
EX2 5DW
Status
Recruiting
Source
University of Birmingham
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT04116047
- ClinicalTrials.gov processed this data on October 09, 2019
Published on BioPortfolio: 2019-10-10T09:39:39-0400
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Medical and Biotech [MESH] Definitions
Radiotherapy, Conformal
Radiotherapy where there is improved dose homogeneity within the tumor and reduced dosage to uninvolved structures. The precise shaping of dose distribution is achieved via the use of computer-controlled multileaf collimators.
Radiotherapy, Adjuvant
Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. Adjuvant radiotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
Radiotherapy, Intensity-modulated
CONFORMAL RADIOTHERAPY that combines several intensity-modulated beams to provide improved dose homogeneity and highly conformal dose distributions.
Radiotherapy Dosage
The total amount of radiation absorbed by tissues as a result of radiotherapy.
Radioimmunotherapy
Radiotherapy where cytotoxic radionuclides are linked to antibodies in order to deliver toxins directly to tumor targets. Therapy with targeted radiation rather than antibody-targeted toxins (IMMUNOTOXINS) has the advantage that adjacent tumor cells, which lack the appropriate antigenic determinants, can be destroyed by radiation cross-fire. Radioimmunotherapy is sometimes called targeted radiotherapy, but this latter term can also refer to radionuclides linked to non-immune molecules (see RADIOTHERAPY).
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