Mother-infant Microbiota Transmission and Its Link to the Health of the Baby

2019-10-11 10:03:45 | BioPortfolio


The human intestinal tract harbors a diverse and complex microbial community, known as gut microbiota, which is critical in sustaining physiology, metabolism, nutrition and immune function. Dysbiosis of gut microbiota has been linked with obesity, hyperglycemia, hyperlipidemia, inflammatory bowel disease and other chronic inflammatory diseases. Gut microbiota is affected by host genetic markup, diet and life style; and therefore varied by human races and geographical locations.

The development of gut microbiota starts before birth. The infant's microbiome can impact on human health in later life. The microbiome of pregnant women are associated with early-life microbiota of their offspring as well as growth, neurodevelopment and the development of allergic and neurocognitive disorders.

Early childhood, when the microbiota is less mature and more malleable, is a golden age for microbiota manipulation to prevent disease. Studying microbiota at this golden age also allow us to dissect the development of a faulty microbiota and identify therapeutic targets to reverse it and cure diseases that are already developed.

Study Design


Gut Microbiome


Not yet recruiting


Chinese University of Hong Kong

Results (where available)

View Results


Published on BioPortfolio: 2019-10-11T10:03:45-0400

Clinical Trials [361 Associated Clinical Trials listed on BioPortfolio]

Effects of H.Pylori Eradication on Microbiome

The aim of this Project is, within the scope of industrial research, to evaluate the long term effects of H.pylori eradication on microbiome (gut microbiome, upper respiratory tract microb...

Maternal and Neonatal Microbiome

The aim of the study is to characterize and monitor the microbiome of premature infants born in the investigators facility until discharge from the NICU. The investigators will also examin...

Microbiome and Sarcopenia in Patients With Liver Cirrhosis

Protein-energy malnutrition (PEM) occurs in 65-90% of patients with liver cirrhosis. Severity of malnutrition correlates with progression of liver disease and leads to sarcopenia in 30-70%...

Food and Microbiome Longitudinal Investigation (FAMiLI)

The NYU Human Microbiome Study Cohort is designed to improve understanding of the role of human microbiome in health and disease. This study will serve as a critical NYU biorepository reso...

Neonatal Microbiome Validity Study

This is a validation study to compare proposed field collection methods with a gold standard collection technique for microbiome analysis of stool and breast milk samples.

PubMed Articles [743 Associated PubMed Articles listed on BioPortfolio]

The impact of microbiome in urological diseases: a systematic review.

The term microbiome is used to signify the ecological community of commensal, symbiotic, and pathogenic microorganisms that share our body space, in which there were increasing evidences to suggest th...

A review of next generation sequencing technologies used in the evaluation of the skin microbiome: what a time to be alive.

The role of the microbiome in healthy and disease states of the human body is progressively being found to extend beyond the gastrointestinal tract and into other organ systems such as the skin. Resea...

Dietary quality and the colonic mucosa-associated gut microbiome in humans.

Despite tremendous interest in modulating the microbiome to improve health, the association between diet and the colonic mucosa-associated gut microbiome in healthy individuals has not been examined.

Recoding the metagenome: microbiome engineering in situ.

Synthetic biology has enabled a new generation of tools for engineering the microbiome, including targeted antibiotics, protein delivery, living biosensors and diagnostics, and metabolic factories. He...

Host Genetics, Diet, and Microbiome: The Role of AMY1.

Host gene variants selected by diet adaptation have been associated with the microbiome. Poole et al. (Cell Host Microbe 2019;25;553-564.E7) reported that AMY1 copy number, associated with obesity, al...

Medical and Biotech [MESH] Definitions

All of the microbial organisms that naturally exist within the GASTROINTESTINAL TRACT.

More From BioPortfolio on "Mother-infant Microbiota Transmission and Its Link to the Health of the Baby"

Quick Search

Relevant Topics

Public Health
Alternative Medicine Cleft Palate Complementary & Alternative Medicine Congenital Diseases Dentistry Ear Nose & Throat Food Safety Geriatrics Healthcare Hearing Medical Devices MRSA Muscular Dyst...

Women's Health
Women's Health - key topics include breast cancer, pregnancy, menopause, stroke Follow and track Women's Health News on BioPortfolio: Women's Health News RSS Women'...

Searches Linking to this Trial