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Comparison of Ketamine and Etomidate During Rapid Sequence Intubation in Trauma Patients

2019-10-15 11:11:04 | BioPortfolio

Summary

In trauma patients with high shock index, the investigators compare the effects on hemodynamics between ketamine and etomidate.

Description

In trauma patients, rapid sequence intubation is recommended. The drug of choice, however, has been debated. One cohort comparative study showed ketamine had benefit in hemodynamics compared to etomidate in trauma patients. One observational study showed in high shock index patients, ketamine showed maintain systolic blood pressure. And other retrospective showed less clinical hypotension was less in ketamine. However there is no randomized controlled study comparing ketamine and etomidate in trauma patients. The purpose of this study is comparing the effects of hemodynamics between ketamine and etomidate in high shock index trauma patients.

Study Design

Conditions

Trauma

Intervention

Etomidate Injection 0.2 mg/kg, Ketamine injection 2 mg/kg

Location

Ajou university school of medicine
Suwon
Gyeonggi-do
Korea, Republic of
16499

Status

Not yet recruiting

Source

Ajou University School of Medicine

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-10-15T11:11:04-0400

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Medical and Biotech [MESH] Definitions

Adverse reactions that occur initially at the site of injection or infusion. Milder type is confined to a local allergic flare reaction. A more severe reaction is caused by extravasation of VESICANTS from the blood vessel at the site of injection and can cause damage to the surrounding tissue. In tumor flare reaction symptoms involve well beyond the injection site such as an increase in the tumor size and tumor markers levels, bone pain, and HYPERCALCEMIA.

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