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A Multicenter Prospective Study of Application of Platelet Mapping in Acute-on-chronic-liver Failure in China

2019-10-15 11:11:19 | BioPortfolio

Summary

Ineffective hemostasis or a paradoxical prothrombotic state of Acute-on-chronic liver disease (ACLF) has been well established. Thrombelastography measures the dynamics of thrombin production and provides a global assessment of coagulation incorporating the cumulative effect of the interactions at various levels between plasma components and cellular component of coagulation. And through the platelet mapping, it can help provide a picture of patients' function of platelet. Based on the primary result of our derivation cohort(NCT03281278), ACLF patients with high ADP inhibition rate had high 28-day mortality.This multicenter validation cohort aims to validate the predictive role of platelet mapping in ACLF prognosis, organ failure developments and short term mortality.

Study Design

Conditions

Thrombelastography

Intervention

standard treatment

Location

Hepatology Unit, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University
Guangzhou
Guangdong
China
510515

Status

Recruiting

Source

Nanfang Hospital of Southern Medical University

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-10-15T11:11:19-0400

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