The Effects of Intravenous Anesthetics and Inhaled Anesthetics on Patients' Postoperative Sleep

2019-10-17 11:03:50 | BioPortfolio


Surgery is a very common treatment in clinical practice. As an important part of surgery, anesthesia is a safe and comfortable pain-free surgical environment, and it is easy to leave sequelae and other negative effects. General anesthesia can lead to postoperative sleep rhythm disorder, and severe cases can develop postoperative operative sleep disturbances (PSD). Postoperative sleep disorders were associated with postoperative hemorrhagic hypoxemia, postoperative pain sensitization, postoperative cognitive dysfunction, and cardiovascular complications such as blood pressure fluctuations caused by sympathetic excitation. In addition, postoperative sleep disorders can increase the number of apneas in patients with sleep apnea, and hypoxemia caused by apnea is an independent risk factor for nocturnal acute myocardial infarction. Normal sleep is divided into non-rapid eye movement sleep (NREM) and rapid eye movement sleep (REM). The sleep characteristic of REM is the presence of rapid eye movement during sleep, which is less stable than NREM and is associated with dreaming and muscle movement. The sleep characteristic of NREM is deep sleep, also known as slow wave sleep. The study found that most intravenous anesthetics and inhaled anesthetics can directly stimulate GABAergic neurons in the Ventrolateral preoptic area (VLPO), and induce anesthesia through endogenous sleep-regulated neural circuits. Among them, the anesthesia induced by intravenous anesthetic propofol can not only replace NREM sleep, but also replace REM sleep; while inhaled anesthetics can not meet REM sleep, and the rebound of REM sleep increases later. Therefore, the choice of anesthetic drugs during surgery has positive significance for the adjustment of postoperative sleep conditions.

Study Design


Sleep Disturbance


Propofol ; Sevoflurane


Not yet recruiting


Shengjing Hospital

Results (where available)

View Results


Published on BioPortfolio: 2019-10-17T11:03:50-0400

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