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Surgery is a very common treatment in clinical practice. As an important part of surgery, anesthesia is a safe and comfortable pain-free surgical environment, and it is easy to leave sequelae and other negative effects. General anesthesia can lead to postoperative sleep rhythm disorder, and severe cases can develop postoperative operative sleep disturbances (PSD). Postoperative sleep disorders were associated with postoperative hemorrhagic hypoxemia, postoperative pain sensitization, postoperative cognitive dysfunction, and cardiovascular complications such as blood pressure fluctuations caused by sympathetic excitation. In addition, postoperative sleep disorders can increase the number of apneas in patients with sleep apnea, and hypoxemia caused by apnea is an independent risk factor for nocturnal acute myocardial infarction. Normal sleep is divided into non-rapid eye movement sleep (NREM) and rapid eye movement sleep (REM). The sleep characteristic of REM is the presence of rapid eye movement during sleep, which is less stable than NREM and is associated with dreaming and muscle movement. The sleep characteristic of NREM is deep sleep, also known as slow wave sleep. The study found that most intravenous anesthetics and inhaled anesthetics can directly stimulate GABAergic neurons in the Ventrolateral preoptic area (VLPO), and induce anesthesia through endogenous sleep-regulated neural circuits. Among them, the anesthesia induced by intravenous anesthetic propofol can not only replace NREM sleep, but also replace REM sleep; while inhaled anesthetics can not meet REM sleep, and the rebound of REM sleep increases later. Therefore, the choice of anesthetic drugs during surgery has positive significance for the adjustment of postoperative sleep conditions.
Propofol ； Sevoflurane
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Published on BioPortfolio: 2019-10-17T11:03:50-0400
Postoperative pain may be affected by general anaesthetics. The effect of propofol and sevoflurane on postoperative pain in chinese female patients has not been demonstrated before. This s...
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To investigate the effect of sevoflurane and propofol on the concentrations of serum homocysteine and folic acid in children who received cochlear implant surgery.
To assess whether sevoflurane provides better haemodynamic stability than propofol in acute right ventricular (RV) ischaemia-reperfusion.
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Propofol is widely used for induction and maintenance of anaesthesia, which causes a rapid loss of consciousness. So far the mechanisms underlying the effect of propofol are still largely unknown. Her...
Complex neurobehavioral disorder characterized by distinctive facial features (FACIES), developmental delay and mental retardation. Behavioral phenotypes include sleep disturbance, maladaptive, self-injurious and attention-seeking behaviors. The sleep disturbance is linked to an abnormal circadian secretion pattern of MELATONIN. The syndrome is associated with de novo deletion or mutation and HAPLOINSUFFICIENCY of the retinoic acid-induced 1 protein on chromosome 17p11.2.
Periods of sleep manifested by changes in EEG activity and certain behavioral correlates; includes Stage 1: sleep onset, drowsy sleep; Stage 2: light sleep; Stages 3 and 4: delta sleep, light sleep, deep sleep, telencephalic sleep.
An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
Rare and often fatal drug complication which affects patients undergoing long-term treatment with high doses of PROPOFOL. It is characterized by METABOLIC ACIDOSIS; HYPERLIPIDEMIA; RHABDOMYOLYSIS; cardiovascular CIRCULATORY COLLAPSE; CARDIAC FAILURE; and KIDNEY FAILURE.
Dyssomnias (i.e., insomnias or hypersomnias) associated with dysfunction of internal sleep mechanisms or secondary to a sleep-related medical disorder (e.g., sleep apnea, post-traumatic sleep disorders, etc.). (From Thorpy, Sleep Disorders Medicine, 1994, p187)
Surgery is a technology consisting of a physical intervention on tissues. All forms of surgery are considered invasive procedures; so-called "noninvasive surgery" usually refers to an excision that does not penetrate the structure being exci...
Anesthesia is the loss of feeling or sensation in all or part of the body. It may result from damage to nerves or can be induced by an anesthetist (a medical professional) using anesthetics such as thiopental or propofol or sevoflurane during a surgical ...
Pain is defined by the International Association for the Study of Pain as “an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage”. Some illnesses can be excruci...