Pioglitazone Treatment for Hyperglycemic Acute Ischemic Stroke
Summary
Study objective is to determine whether Pioglitazone (PGZ) can improve clinical outcomes in hyperglycemic acute ischemic stroke (IS). The rationale for the proposed research is to develop an acute intervention that can improve neurological recovery and decrease mortality and morbidity in high-risk diabetic stroke patients.
Study Design
Conditions
Stroke, Acute
Intervention
Pioglitazone 45 mg, Placebo oral tablet
Status
Not yet recruiting
Source
Milton S. Hershey Medical Center
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT04123067
- ClinicalTrials.gov processed this data on October 16, 2019
Published on BioPortfolio: 2019-10-17T11:03:51-0400
Clinical Trials
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Insulin Resistance Intervention After Stroke Trial
The purpose of this study is to determine if pioglitazone is effective in preventing future strokes or heart attacks among non-diabetic persons who have had a recent ischemic stroke.
Measuring Ambulation, Motor, and Behavioral Outcomes With Post-Stroke Fluoxetine in Tanzania
This is a phase II, randomized study of 120 adults age 18 or above who will prescribed 20mg daily Fluoxetine for 90 days following acute, ischemic stroke.
Study to investigate if the study drug ticagrelor and ASA is more effective than Placebo (inactive tablet) and ASA in preventing new stroke events.
Pioglitazone, a medication of thiazolidinedione group, is capable of triggering the peroxisome proliferator-activated receptors (PPAR-γ). Activation of receptor PPAR-γ regulates carbohyd...
PubMed Articles
Patients with atrial fibrillation (AF) who suffer an acute ischemic stroke are at risk for both hemorrhagic transformation and recurrent ischemic stroke in the acute post-stroke period. Oral anticoagu...
To establish how oral bacteria are related to cough sensitivity and pneumonia in a clinical stroke population.
Direct Oral Anticoagulant Plasma Levels for the Management of Acute Ischemic Stroke.
The management of acute ischemic stroke in patients on direct oral anticoagulants (DOACs) is challenging. However, the substance-specific plasma level could guide treatment decisions on recanalization...
A growing number of studies have shown that thiazolidinedoniones(TZD) can be antipsoriatic. Pioglitazone is a representative of the class of antidiabetic drugs known as TZD. TZD can activate nuclear p...
Exploratory Analysis of Oral Glibenclamide in Acute Ischemic Stroke.
Intravenous glibenclamide (GBC) exerts neuroprotection in both preclinical and preliminary clinical studies. This study explored the safety and potential efficacy of oral GBC in patients with acute he...
Medical and Biotech [MESH] Definitions
Stroke Rehabilitation
Restoration of functions to the maximum degree possible in a person or persons suffering from a stroke.
Karoshi Death
Sudden death from overwork, most often as a result of acute CARDIOVASCULAR STROKE.
Stroke, Lacunar
Stroke caused by lacunar infarction or other small vessel diseases of the brain. It features hemiparesis (see PARESIS), hemisensory, or hemisensory motor loss.
Oral Medicine
A branch of dentistry dealing with diseases of the oral and paraoral structures and the oral management of systemic diseases. (Hall, What is Oral Medicine, Anyway? Clinical Update: National Naval Dental Center, March 1991, p7-8)
Therapeutic Misconception
Misunderstanding among individuals, frequently research subjects, of scientific methods such as randomization and placebo controls.
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