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This is a multi-center, first-in-human, non-randomized, open-label, single-arm, dose-escalation Phase I study to evaluate the safety and tolerability of MAX-10181 in patients with advanced solid tumor.
Currently, immunotherapy of PD-1/L1 inhibition is gaining the leadership role due to its durable response to some tumors and low occurrence of side effects. Since the current FDA approved anti-PD-1/L1 antibodies work for only 20-30% of the patients.
MAX-10181 is orally active with activity similar to FDA approved antibody Durvalumab. In combination study, it improved the therapeutic efficacy for both anti-PD-L1 Durvalumab and anti-PD-1 Nivolumab. It also penetrates BBB for potential use in brain tumor. More importantly, it demonstrated excellent safety profile in rats and dogs.
These attributes support further studies in human clinical trials.
Not yet recruiting
Maxinovel Pty., Ltd.
Published on BioPortfolio: 2019-10-15T11:10:48-0400
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A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.
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In a clinical trial or interventional study, participants receive specific interventions according to the research plan or protocol created by the investigators. These interventions may be medical products, such as drugs or devices; procedures; or change...
Biological therapy involves the use of living organisms, substances derived from living organisms, or laboratory-produced versions of such substances to treat disease. Some biological therapies for cancer use vaccines or bacteria to stimulate the body&rs...