Euphrasia Eye Drops in Preterm Infants With First Signs of Congestion of Nasolacrimal Duct

2019-10-14 10:28:48 | BioPortfolio


Congenital nasolacrimal duct obstruction (CNLDO) occurs in approximately 10 to 20% of all term newborns, and is the most common cause of persistent tearing and ocular discharge in children. CNLDO causes symptoms in up to 6% of children during the first year of life. The first clinical signs appear during the first month of life in 95% of cases and usually consist of tearing and debris on the eyelashes ("mattering"). Mucopurulent eye discharge occurs commonly in infants with CNLDO and, in the absence of other signs of infection, suggests bacterial overgrowth in the stagnant tear pool of the lacrimal sac.

This study investigates whether early administration of Euphrasia eye drops (Weleda AG, Arlesheim) in preterm neonates presenting with first ocular discharge with or without tearing and reddened eye fosters the resolution of the ocular discharge and reduces the need for topical antibiotic therapy.

Study Design


Congenita Nasolacrimal Duct Obstruction


Euphrasia Officinalis Preparation, Placebo


Department of Neonatology, Children University Hospital of Bern




University of Bern

Results (where available)

View Results


Published on BioPortfolio: 2019-10-14T10:28:48-0400

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PubMed Articles [3704 Associated PubMed Articles listed on BioPortfolio]

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Medical and Biotech [MESH] Definitions

Interference with the secretion of tears by the lacrimal glands. Obstruction of the lacrimal sac or nasolacrimal duct causing acute or chronic inflammation of the lacrimal sac (DACRYOCYSTITIS). It is caused also in infants by failure of the nasolacrimal duct to open into the inferior meatus and occurs about the third week of life. In adults occlusion may occur spontaneously or after injury or nasal disease. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p250)

A tubular duct that conveys TEARS from the LACRIMAL GLAND to the nose.

Surgical fistulization of the lacrimal sac for external drainage of an obstructed nasolacrimal duct.

A group of inherited ectodermal dysplasias whose most prominent clinical feature is hypertrophic nail dystrophy resulting in PACHYONYCHIA. Several specific subtypes of pachyonychia congenita have been associated with mutations in genes that encode KERATINS.

The largest bile duct. It is formed by the junction of the CYSTIC DUCT and the COMMON HEPATIC DUCT.

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