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A Study in Subjects With Advanced Cancer

2019-10-16 10:39:38 | BioPortfolio

Summary

This is a Phase I open-label, 3+3 dose escalation design Phase I trial to assess the safety, tolerability and dose-limiting toxicity (DLT) of AGEN2373 as monotherapy in subjects with solid tumors.

Description

This is a Phase I open-label, dose escalation study of AGEN2373, an Anti-CD137 Monoclonal Antibody being assessed as monotherapy in subjects with solid tumors. The study is a 3+3 dose escalation design and the maximum recommended starting dose (RSD) was derived from the minimally anticipated biological effect level (MABEL). AGEN2373 will be administered via continuous IV infusion on Day 1 of each 4-week cycle for up to 2 years or until disease progression or unacceptable toxicity. The primary objectives are to assess the safety, tolerability, and DLT of AGEN2373 as monotherapy in subjects with advanced solid tumors and to determine the recommended Phase 2 dose (RP2D).

Study Design

Conditions

Advanced Cancer

Intervention

AGEN2373

Location

Columbia University
New York
New York
United States
10032

Status

Not yet recruiting

Source

Agenus Inc.

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-10-16T10:39:38-0400

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