Contributions of mTBI to Neurodegeneration Due to CTE and Alzheimer's Disease

2019-10-17 11:03:44 | BioPortfolio


This is a research study that aims to examine whether veterans with mild Traumatic Brain Injuries are at risk for dementia by studying their memory, brain wave activity, brain structure and proteins that can be elevated after brain injury and in dementia.


The specific aim of this project is to examine whether veterans with mild Traumatic Brain Injuries are at risk for dementia by studying their memory, brain wave activity, brain structure and proteins that can be elevated after brain injury and in dementia.

This study will recruit patients with a history of mild-moderate traumatic brain injury, mild cognitive impairment, as well as healthy controls in order to better understand how single or repetitive mild Traumatic brain injuries may contribute to the development of dementia. It will be prospective in nature. Participants will be asked to complete a series of 3 study sessions. During the first study session, each subject will be asked to complete a neuropsychological assessment. If the subject's testing scores fall under the study criteria, they will also be asked to complete a computer task. In the second study session, we will measure the subjects brain waves using an EEG while they complete a computer task. During the computer task the subjects will be asked to study a list of words and we will test the subjects on their memory for those words. During the final study session, we will ask subjects to complete: (1) an MRI, (2) a standard blood draw procedure, and (3) a lumbar puncture procedure.

Clinical Implications: These studies will provide a better understanding of which individuals with Traumatic Brain Injury will develop dementia, and how many years in the future dementia may occur.

Study Design


Mild Traumatic Brain Injury


No Intervention is used for this study but all subjects will be asked to complete EEG testing and an MRI scan., No intervention is used for this study but all subjects will be asked to complete a venous blood draw procedure and a lumbar puncture procedure


VA Boston Healthcare System
Jamaica Plain
United States


Not yet recruiting


VA Boston Healthcare System

Results (where available)

View Results


Published on BioPortfolio: 2019-10-17T11:03:44-0400

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