Topics

A Study to Assess the Drug-drug Interaction of BMS-963272 and Rosuvastatin

2019-10-17 11:03:45 | BioPortfolio

Summary

Phase 1 study that assesses the effect of BMS-963272 on exposure of rosuvastatin in healthy participants

Study Design

Conditions

Healthy Participants

Intervention

rosuvastatin, BMS-963272

Location

Local Institution
Salt Lake City
Utah
United States
84124

Status

Not yet recruiting

Source

Bristol-Myers Squibb

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-10-17T11:03:45-0400

Clinical Trials [1185 Associated Clinical Trials listed on BioPortfolio]

A Multiple Dose Study to Assess the Safety and Tolerability of BMS-963272 in Obese But Otherwise Healthy Adults

This study will assess the safety and tolerability of multiple doses of BMS-963272 in obese but otherwise healthy participants.

Study of PF-04965842 Effect on Rosuvastatin Pharmacokinetics in Healthy Participants

This is a Phase 1, randomized, 2 way crossover, multiple dose, open label study of the effect of PF 04965842 on rosuvastatin PK in healthy participants. Participants will be randomized to ...

A Study of LY3314814 in Healthy Participants When Taken With Rosuvastatin

The purpose of this study is to evaluate the effect of LY3314814 on rosuvastatin. The amount of rosuvastatin in the blood will be compared, when taken alone, and then when taken with LY331...

A Study of PF-06651600 Effect on Rosuvastatin Pharmacokinetics in Healthy Participants

A phase 1, 2-period, fixed-sequence, multiple-dose, open-label study of the effect of PF-06651600 on Rosuvastatin pharmacokinetics in healthy participants. Approximately 12 healthy male an...

A Pharmacokinetic Interaction Study Between JNJ-54861911 and Transporter Substrates Rosuvastatin and Metformin in Healthy Participants

The purpose of this study is to look at how taking JNJ-54861911 every day will effect the amount of rosuvastatin or metformin in your blood after taking only a single dose of either one.

PubMed Articles [8056 Associated PubMed Articles listed on BioPortfolio]

No Effect of Digoxin on Rosuvastatin Pharmacokinetics in Healthy Subjects: Utility of Oita Combination for Clinical Drug-Drug Interaction Study.

This study evaluated the utility of combination of digoxin (0.25 mg) and rosuvastatin (5 mg) as a new transporter (P-gp/BCRP/OATP1B1/OATP1B3) probe cocktail (Oita combination) for drug-drug interactio...

Effects of rosuvastatin on the immune system in healthy volunteers with normal serum cholesterol.

Hydroxymethyl-glutaryl-coenzyme A reductase inhibitors ('statins') are prescribed to millions of people. Statins are anti-inflammatory independent of their cholesterol-reducing effects. To date, most ...

PET Imaging of CRosuvastatin Hepatic Concentrations and Hepatobiliary Transport in Humans in the Absence and Presence of Cyclosporine A.

Using positron emission tomography (PET) imaging, we determined the hepatic concentrations and hepatobiliary transport of [ C]rosuvastatin (IV injection) in the absence (n=6) and presence (n=4 of 6) o...

Effects of Food and Gender on Pharmacokinetics of Rosuvastatin in a Chinese Population Based on 4 Bioequivalence Studies.

The effects of food and gender on the pharmacokinetics of rosuvastatin in healthy Chinese subjects were investigated from 4 bioequivalence studies. These studies were designed as randomized, open-labe...

Rosuvastatin Attenuates acute nephrotoxicity through modulation of oxidative stress in Sprague Dawley rats.

To assess the reno-protective effect of rosuvastatin on gentamicin-induced nephrotoxicity in rats.

Medical and Biotech [MESH] Definitions

Works about clinical studies in which participants may receive diagnostic, therapeutic, or other types of interventions, but the investigator does not assign participants to specific interventions (as in an interventional study).

A work that reports on the results of a clinical study in which participants may receive diagnostic, therapeutic, or other types of interventions, but the investigator does not assign participants to specific interventions (as in an interventional study).

Healthy People Programs are a set of health objectives to be used by governments, communities, professional organizations, and others to help develop programs to improve health. It builds on initiatives pursued over the past two decades beginning with the 1979 Surgeon General's Report, Healthy People, Healthy People 2000: National Health Promotion and Disease Prevention Objectives, and Healthy People 2010. These established national health objectives and served as the basis for the development of state and community plans. These are administered by the Office of Disease Prevention and Health Promotion (ODPHP). Similar programs are conducted by other national governments.

A HYDROXYMETHYLGLUTARYL-COA-REDUCTASE INHIBITOR, or statin, that reduces the plasma concentrations of LDL-CHOLESTEROL; APOLIPOPROTEIN B, and TRIGLYCERIDES while increasing HDL-CHOLESTEROL levels in patients with HYPERCHOLESTEROLEMIA and those at risk for CARDIOVASCULAR DISEASES.

Governmental guidelines and objectives pertaining to public food supply and nutrition including recommendations for healthy diet and changes in food habits to ensure healthy diet.

More From BioPortfolio on "A Study to Assess the Drug-drug Interaction of BMS-963272 and Rosuvastatin"

Quick Search

Relevant Topics

Statins
Statins (or HMG-CoA reductase inhibitors) are a class of drug used to lower cholesterol levels by inhibiting the enzyme HMG-CoA reductase, which plays a central role in the production of cholesterol in the liver. Increased cholesterol levels have been as...

The Top 100 Pharmaceutical Companies
Top 10 biotech and pharmaceutical companies worldwide based on market value in 2015 2015 ranking of the global top 10 biotech and pharmaceutical companies based on revenue (in billion U.S. dollars) Johnson & Johnson, U.S. 74...


Searches Linking to this Trial