Multiple Doses of DM199 in Patients With Chronic Kidney Disease

2019-10-17 11:03:47 | BioPortfolio


An open-label, Phase II, multi-center study evaluating multiple doses of DM199 in participants with chronic kidney disease.


This is an open-label, Phase II, multi-center study evaluating DM199 in approximately 60 (sixty) Participants in two cohorts.

Cohort I: African Americans with CKD (Stage II or III), hypertension and non-diabetic Cohort II: Participants with IgA nephropathy diagnosis and CKD (Stage II or III)

Participants in each cohort will be enrolled in a parallel assignment to one of two doses:

Dose 1: DM199 2.0 µg/kg SC 2x week for 95 days Dose 2: DM199 5.0 µg/kg SC 2x week for 95 days

Study Design


Kidney Diseases




Not yet recruiting


DiaMedica Therapeutics Inc

Results (where available)

View Results


Published on BioPortfolio: 2019-10-17T11:03:47-0400

Clinical Trials [1581 Associated Clinical Trials listed on BioPortfolio]

A Study to Asses Pharmacokinetics, Safety, and Tolerability of DM199 in Patients With Diabetes Mellitus and Chronic Kidney Disease

An open-label, phase IB, multi-center study evaluating DM199 in subjects with Type 1 Diabetes or Type 2 Diabetes and Stage 3 or 4 Chronic Kidney Disease. The primary objectives of this stu...

An Open Label, Phase 1b, Ascending Dose Study of DM199

This is a Phase 1B study to assess the safety, tolerability and pharmacokinetics of DM199 in healthy volunteers. The study will be consist of two parts: Part A will focus on intravenous do...

Changes of Ocular Structures After Hemodialysis in Patients With Chronic Kidney Diseases

To evaluate the effect of hemodialysis on various ophthalmologic parameters in patients with end-stage kidney disease (ESRD).

Dextromethorphan and Silymarin in Chronic Kidney Disease (CKD) Patients

The investigators test the renal and cardiovascular protective effects dextromethorphan and silymarin on patients with the proteinuric chronic kidney diseases, who enrolled in our clinical...

Volume 3D_US Kidney

The purpose of this study is to measure the volume of the kidney and tumors using 3D-US acquisition and to correlate these measurements to contrast-enhanced CT or MRI.

PubMed Articles [10169 Associated PubMed Articles listed on BioPortfolio]

Multicystic Dysplastic Kidney and Incontinentia Pigmenti: Coexistence of 2 Rare Diseases.

Multicystic dysplastic kidney is a congenital kidney malformation consisting of multiple cysts of various sizes without a normal kidney morphology. Incontinentia pigmenti is a rare X-linked dominant g...

Incidence and Prognosis of Acute Kidney Diseases and Disorders Using an Integrated Approach to Laboratory Measurements in a Universal Health Care System.

Abnormal measurements of kidney function or structure may be identified that do not meet criteria for acute kidney injury (AKI) or chronic kidney disease (CKD) but nonetheless may require medical atte...

Hypertension management in chronic kidney diseases : an unachieved symphony.

Arterial hypertension (HT) affects hundreds millions of people suffering from chronic kidney disease: it could be a cause or a consequence. HT can aggravate their prognosis and then lead to a very hig...

Cell Apoptosis and Autophagy in Renal Fibrosis.

Renal fibrosis is the final common pathway of all chronic kidney diseases progressing to end-stage renal diseases. Autophagy, a highly conserved lysosomal degradation pathway, plays important roles in...

Kinetics of Vascular Endothelial Growth Factor and Endothelin 1 Levels in Acute Kidney Injury.

Medical and Biotech [MESH] Definitions

A complication of kidney diseases characterized by cell death involving KIDNEY PAPILLA in the KIDNEY MEDULLA. Damages to this area may hinder the kidney to concentrate urine resulting in POLYURIA. Sloughed off necrotic tissue may block KIDNEY PELVIS or URETER. Necrosis of multiple renal papillae can lead to KIDNEY FAILURE.

Abnormal enlargement or swelling of a KIDNEY due to dilation of the KIDNEY CALICES and the KIDNEY PELVIS. It is often associated with obstruction of the URETER or chronic kidney diseases that prevents normal drainage of urine into the URINARY BLADDER.

Component of the NATIONAL INSTITUTES OF HEALTH. It conducts and supports basic and applied research for a national program in diabetes, endocrinology, and metabolic diseases; digestive diseases and nutrition; and kidney, urologic, and hematologic diseases. It was established in 1948.

A heterogeneous group of hereditary and acquired disorders in which the KIDNEY contains one or more CYSTS unilaterally or bilaterally (KIDNEY, CYSTIC).

Either a single or a single functioning kidney due to NEPHRECTOMY, birth defects or other kidney diseases.

More From BioPortfolio on "Multiple Doses of DM199 in Patients With Chronic Kidney Disease"

Quick Search

Relevant Topics

Clincial Trials
In a clinical trial or interventional study, participants receive specific interventions according to the research plan or protocol created by the investigators. These interventions may be medical products, such as drugs or devices; procedures; or change...

Pulmonary Hypertension
Pulmonary arterial hypertension (PAH) is a chronic, life-threatening disorder characterized by abnormally high blood pressure in the arteries between the heart and lungs of affected individuals. Symptoms can range from mild breathles...

Searches Linking to this Trial