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A Pilot Study of BXCL701 in Patients With Pancreatic Cancer

2019-10-17 11:03:47 | BioPortfolio

Summary

A study to assess the biochemical and immunomodulatory effects of BXCL701 in pancreatic cancer.

Description

This is a Phase 0 or "window of opportunity" study where paired specimen analysis, taken before and after drug exposure, will permit the evaluation of target modulation and assessment of immune effector cell infiltration into the tumor and the generation of relevant immune cytokines.

In this study, BXCL701 will be administered at a dose of 0.6 mg, once daily (the previously defined maximum tolerated dose [MTD] of the drug), to all patients for a short period of 14 days. This study is designed to assess the biochemical and immunomodulatory effects of BXCL701 in pancreatic cancer.

Study Design

Conditions

Cancer of Pancreas

Intervention

Talabostat Mesylate

Status

Not yet recruiting

Source

BioXcel Therapeutics Inc

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-10-17T11:03:47-0400

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Medical and Biotech [MESH] Definitions

The transference of a pancreas from one human or animal to another.

The major component (about 80%) of the PANCREAS composed of acinar functional units of tubular and spherical cells. The acinar cells synthesize and secrete several digestive enzymes such as TRYPSINOGEN; LIPASE; AMYLASE; and RIBONUCLEASE. Secretion from the exocrine pancreas drains into the pancreatic ductal system and empties into the DUODENUM.

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Star-shaped, myofibroblast-like cells located in the periacinar, perivascular, and periductal regions of the EXOCRINE PANCREAS. They play a key role in the pathobiology of FIBROSIS; PANCREATITIS; and PANCREATIC CANCER.

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