Expression of Trefoil Factors and Adrenomedullin in Subjects With Chronic Periodontitis and Coronary Heart Disease
Summary
To assess the demographic variables, periodontal parameters and to determine the expression of Trefoil factors 2 and 3 and Adrenomedullin in unstimulated saliva samples of periodontally healthy subjects with coronary heart disease and generalised chronic periodontitis subjects with and without coronary heart disease.
Description
A total of 75 subjects will be recruited for the study based on the power of the study.
The selected subjects will be divided into 3 groups based on inclusion and exclusion criteria.
GROUP I:25Generalized chronic periodontitis subjects without coronary heart disease.
GROUP II: 25Generalized chronic periodontitis subjects diagnosed with coronary heart disease.
GROUP III: 25Periodontally healthy subjects diagnosed with coronary heart disease.
Demographic variables, periodontal parameters and biochemical parameters will be measured in all three groups
Study Design
Conditions
Coronary Heart Disease
Location
Meenakshi Ammal Dental College
Chennai
Tamil Nadu
India
600095
Status
Recruiting
Source
Meenakshi Ammal Dental College and Hospital
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT04127474
- ClinicalTrials.gov processed this data on October 18, 2019
Published on BioPortfolio: 2019-10-21T12:45:33-0400
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Medical and Biotech [MESH] Definitions
Coronary Aneurysm
Abnormal balloon- or sac-like dilatation in the wall of CORONARY VESSELS. Most coronary aneurysms are due to CORONARY ATHEROSCLEROSIS, and the rest are due to inflammatory diseases, such as KAWASAKI DISEASE.
Myocardial Ischemia
A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
Coronary Disease
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
Bland White Garland Syndrome
A congenital coronary vessel anomaly in which the left main CORONARY ARTERY originates from the PULMONARY ARTERY instead of from AORTA. The congenital heart defect typically results in coronary artery FISTULA; LEFT-SIDED HEART FAILURE and MITRAL VALVE INSUFFICIENCY during the first months of life.
Coronary Artery Bypass, Off-pump
Coronary artery bypass surgery on a beating HEART without a CARDIOPULMONARY BYPASS (diverting the flow of blood from the heart and lungs through an oxygenator).
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