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This is a dietary intervention study in students and staff of Westlake University, which is designed to provide evidence in support of N-of-1 methods as an approach to advance personalized nutrition. The primary aim is using a series of N-of-1 trials to determine the impacts of a high fat, low carbohydrate diet (HF-LCD) on glucose metabolism and gut microbiota in subjects versus a low fat, high carbohydrate diet (LF-HCD) at both the individual and group level.
This study will employ a series of individual N-of-1 trials comparing a high fat, low carbohydrate diet (HF-LCD) to a low fat, high carbohydrate diet (LF-HCD). Participants will enter the study on a usual diet and will have a 6-day run in period for diet planning and baseline data collection before beginning their assigned diet treatment. Treatment periods will be assigned in blocks of two (e.g., AB) with the goal of each subject completing two balanced treatment blocks (e.g., ABAB) where treatment 'A' represents HF-LCD and treatment 'B' represents LF-HCD. Participants will be randomized to either the HF-LCD or the LF-HCD as their starting intervention and alternate between these two conditions for six 6-day treatment periods. There will be a wash-out period lasting for 6 days with normal diet between two interventions to eliminate previous intervention effects. Investigators will aggregate the results of the completed N-of-1 trials across all participants to estimate the group level impacts of HF-LCD compared to LF-HCD.
High fat low carbohydrate diet, Low fat high carbohydrate diet
Published on BioPortfolio: 2019-10-18T11:21:39-0400
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A diet that consists mainly of foods with a high content of protein and limited amounts of CARBOHYDRATES.
A diet that contains limited amounts of CARBOHYDRATES. This is in distinction to a regular DIET.
A diet rich in DIETARY CARBOHYDRATES.
A diet prescribed in the treatment of diabetes mellitus, usually limited in the amount of sugar or readily available carbohydrate. (Dorland, 27th ed)
A diet that includes foods with a high protein content.
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