Is 10 Injections of Bladder Botox Less Painful Than 20 Injections?

2019-10-18 11:21:43 | BioPortfolio


The purpose of this research study is to help determine if 10 injections of Botox ® 100 units is less painful than 10 injections of Botox ® 100 units based on effectiveness in reducing urge incontinence episodes. Study will also be assessed for the pain of procedure and adverse outcomes of 20 injections versus 10 injections.


This study is a randomized clinical trial to assess whether or not 10 injections of 100 units of intradetrusor Botox® toxin is perceived as less painful compared to 20 injections of 100 units of intradetrusor Botox® toxin for the treatment of refractory overactive bladder.

Study Design


Overactive Bladder


OnabotulinumtoxinA 100 UNT


Urology clinic locations at Wake Forest Baptist Medical Center
North Carolina
United States


Not yet recruiting


Wake Forest University Health Sciences

Results (where available)

View Results


Published on BioPortfolio: 2019-10-18T11:21:43-0400

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PubMed Articles [763 Associated PubMed Articles listed on BioPortfolio]

A Patient-Centered Approach to Refractory Overactive Bladder and Barriers to Third-Line Therapy.

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Medical and Biotech [MESH] Definitions

Symptom of overactive detrusor muscle of the URINARY BLADDER that contracts with abnormally high frequency and urgency. Overactive bladder is characterized by the frequent feeling of needing to urinate during the day, during the night, or both. URINARY INCONTINENCE may or may not be present.

Symptoms of disorders of the lower urinary tract including frequency, NOCTURIA; urgency, incomplete voiding, and URINARY INCONTINENCE. They are often associated with OVERACTIVE BLADDER; URINARY INCOMPETENCE; and INTERSTITIAL CYSTITIS. Lower urinary tract symptoms in males were traditionally called PROSTATISM.

A HERNIA-like condition in which the weakened pelvic muscles cause the URINARY BLADDER to drop from its normal position. Fallen urinary bladder is more common in females with the bladder dropping into the VAGINA and less common in males with the bladder dropping into the SCROTUM.

Involuntary discharge of URINE as a result of physical activities that increase abdominal pressure on the URINARY BLADDER without detrusor contraction or overdistended bladder. The subtypes are classified by the degree of leakage, descent and opening of the bladder neck and URETHRA without bladder contraction, and sphincter deficiency.

An abnormal passage in the URINARY BLADDER or between the bladder and any surrounding organ.

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