A Study on Central Transport Characteristics of Flurbiprofen Axetil in Elderly Patients

2019-10-21 12:45:26 | BioPortfolio


The project will apply the methods of clinical observation experiment to study the central transport characteristics of flurbiprofen axetil by detecting S-flurbiprofen and R-flurbiprofen concentrations in cerebral-spinal fluid(CSF) after intravenous injection of flurbiprofen axetil in elderly patients.


The patients undergoing spinal anesthesia for lower extremity surgery will be studied. Flurbiprofen axetil 100mg will be injected intravenously. CSF 1ml and blood 2ml will be obtained simultaneously every 5 minutes after intravenous injection in 50 min( T1~T10).CSF and blood samples will be used to detected S-flurbiprofen and R-flurbiprofen concentrations by using Liquid Chromatography-Mass Spectrometry. And the CSF/blood S-flurbiprofen and R-flurbiprofen concentrations ratio were calculated.

Study Design


Flurbiprofen Axetil


Peking University People's Hospital




Peking University People's Hospital

Results (where available)

View Results


Published on BioPortfolio: 2019-10-21T12:45:26-0400

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