A Study on Central Transport Characteristics of Flurbiprofen Axetil in Elderly Patients
Summary
The project will apply the methods of clinical observation experiment to study the central transport characteristics of flurbiprofen axetil by detecting S-flurbiprofen and R-flurbiprofen concentrations in cerebral-spinal fluid(CSF) after intravenous injection of flurbiprofen axetil in elderly patients.
Description
The patients undergoing spinal anesthesia for lower extremity surgery will be studied. Flurbiprofen axetil 100mg will be injected intravenously. CSF 1ml and blood 2ml will be obtained simultaneously every 5 minutes after intravenous injection in 50 min( T1~T10).CSF and blood samples will be used to detected S-flurbiprofen and R-flurbiprofen concentrations by using Liquid Chromatography-Mass Spectrometry. And the CSF/blood S-flurbiprofen and R-flurbiprofen concentrations ratio were calculated.
Study Design
Conditions
Flurbiprofen Axetil
Location
Peking University People's Hospital
Beijing
Beijing
China
100044
Status
Recruiting
Source
Peking University People's Hospital
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT04128410
- ClinicalTrials.gov processed this data on October 18, 2019
Published on BioPortfolio: 2019-10-21T12:45:26-0400
Clinical Trials
Flurbiprofen Axetil for Uterine Contraction Pain
Uterine contraction pain is a common problem after abortion. Optimal analgesic for such suffering is still needed to be guaranteed. Flurbiprofen Axetil is a target-distributable non-steroi...
Dexamethasone, Flurbiprofen Axetil and Delirium After Lung Cancer Surgery
Delirium is a common complication in elderly patients after surgery. And its occurrence is associated with worse outcomes. The causes of delirium are multifactorial but may include pain, s...
Postoperative Pain and Discomfort After Orbital Decompression
The purpose of this study is to evaluate the postoperative pain and discomfort using flurbiprofen axetil or nalbuphine administration after orbital decompression under general anesthesia.
Dexamethasone, Flurbiprofen Axetil and Long-term Survival After Lung Cancer Surgery
Surgical resection is the first choice treatment for patients with non-small-cell lung cancer. Despite of advances in surgical techniques, the long-term survival rate of postoperative pati...
Postoperative Pain and Discomfort After Oculoplastic Surgery
The purpose of this study is to evaluate the postoperative pain and discomfort using flurbiprofen axetil or nalbuphine administration after oculoplastic surgery under general anesthesia.
PubMed Articles
Flurbiprofen inhibits androgen productions in rat immature Leydig cells.
Flurbiprofen is one of the nonsteroidal anti-inflammatory drugs. Whether flurbiprofen affects androgen biosynthesis in Leydig cells is still unknown. Immature Leydig cells (ILCs) isolated from 35-day-...
Wastewater treatment plants are a major pathway for pharmaceuticals to the aquatic environment. Many pharmaceuticals, including non-steroidal anti-inflammatory drugs (NSAIDs), are chiral chemicals and...
This study aimed to determine the effect of intraoperative administration of flurbiprofen on postoperative levels of programmed death-1 (PD-1) in patients undergoing thoracoscopic surgery.
The inherent amyloidogenic potentialof wild type transthyretin (TTR) is enhanced by a large number of point mutations, which destabilize the TTR tetramer, thereby promoting its disassembly and patholo...
This study aimed to develop a dual action, namely anti-inflammatory and antimicrobial, nanogel (NG) for the treatment of periodontitis using triclosan (TCS) and flurbiprofen (FLB). Triclosan, an antim...
Medical and Biotech [MESH] Definitions
Flurbiprofen
An anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal disease by inhibiting CARBONIC ANHYDRASE.
More From BioPortfolio on "A Study on Central Transport Characteristics of Flurbiprofen Axetil in Elderly Patients"
Quick Links
Advanced Search |
Login |
Subscribe |
RSS 
BioPortfolio Twitter Channels (200+ Accounts)
LinkedIn