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Aerosol Particle Size and Breathing Pattern During Inhaled Furosemide

2019-10-24 12:49:55 | BioPortfolio

Summary

The study hypothesises that the variability in relief of air hunger with inhaled furosemide that is reported in previous studies can be explained by the breathing pattern adopted during the inhalation and the droplet size in the aerosol, both of which would influence the site of deposition of the aerosol in the lungs

Description

Recent studies suggest that inhaling furosemide as a mist reduces air hunger in healthy volunteers in whom air hunger is induced experimentally in the lab. However, how much reduction varies among individuals. It is not known if the way the mist is breathed (slow/deep or fast/shallow) or the size of the droplets in the mist (large or small) can explain the variation in relief. Both of these factors can influence the site of deposition of the aerosol in the lungs

In this study the relief of air hunger (induced by hypercapnia and constrained ventilation) will be compared when furosemide is inhaled quickly or slowly, and when the mist has large or small droplets. 20 healthy volunteers will be recruited. After a practice session, the 'air hunger' test will be performed before and after 4ml of a 10mg/ml solution of furosemide (40mg). This will be repeated on 4 separate test days using a different method of inhaling the furosemide on each day.

Study Design

Conditions

Healthy Volunteers

Intervention

Inhaled furosemide

Location

Oxford Brookes University
Oxford
Oxfordshire
United Kingdom
OX3 0BP

Status

Recruiting

Source

Oxford Brookes University

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-10-24T12:49:55-0400

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