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The Recovery in Stroke Using PAP Study

2019-10-23 13:11:49 | BioPortfolio

Summary

The proposed study is a randomized controlled trial among 180 patients with acute ischemic stroke and mod/severe OSA diagnosed by ambulatory PSG comparing PAP treatment with usual care concerning the primary outcome of functional recovery.

Description

This study has 3 main aims and an additional exploratory aim.

Specific aim 1: Test whether PAP treatment for OSA in ischemic stroke improves stroke severity, post-stroke symptoms, post-stroke functional recovery (primary outcome), and quality of life.

Specific aim 2: Determine whether acute vs. subacute initiation of PAP in ischemic stroke results in greater improvement in post-stroke outcomes (stroke severity, symptoms, stroke recovery, quality of life).

Specific Aim 3: Conduct in-depth qualitative interviews with 25-30 stroke patients, family members, and acute care providers to elicit their experience with PAP use, including factors that influence adherence.

Exploratory aim: Evaluate whether polysomnographic measures have prognostic utility in understanding the variability in stroke recovery.

Study Design

Conditions

Ischemic Stroke

Intervention

PAP, HLE

Location

Yale University
New Haven
Connecticut
United States
06519

Status

Recruiting

Source

Yale University

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-10-23T13:11:49-0400

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Medical and Biotech [MESH] Definitions

The application of repeated, brief periods of vascular occlusion at the onset of REPERFUSION to reduce REPERFUSION INJURY that follows a prolonged ischemic event. The techniques are similar to ISCHEMIC PRECONDITIONING but the time of application is after the ischemic event instead of before.

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