Track topics on Twitter Track topics that are important to you
Migraine is a significant health problem in the United States with 34 million Americans suffering from migraine attacks every year. High flow oxygen has been successfully used in several clinical studies and shows to reduce headaches by reducing vasoconstriction. Some researchers have suggested cooling mechanism of oxygen as a possible mechanism. The main objective is to test the hypothesis that the pain relief obtained during high flow trans-nasal gas therapy is gas therapy is due to the cooling effect on the nasal mucosa. The study entails recruiting patients from a headache clinic, being escorted to the Institute for Clinical and Translational Research (ICTR) Johns Hopkins Bayview and randomized into different groups (humidified oxygen, dry air, humidified air and dry oxygen). Eventually, patients will be asked to fill out a questionnaire on pain, nausea, sound and light sensitivity graded on a scale of 1-10. Readings are noted at baseline, 15 mins, 2 hours and 24 hours post-therapy.
Migraine headaches are associated with significant impairment of quality of life and loss of productivity. High flow oxygen has been successfully used in several clinical trials and vasoconstriction of blood vessels has been postulated as a possible mechanism. However, some researchers have proposed cooling effect as a possible mechanism. The main objective is to test the hypothesis that the pain relief obtained during high flow intranasal gas therapy is due to the cooling effect on the nasal mucosa. Patients for this study are recruited from the patients who are already scheduled to attend the headache clinic staffed by the principal investigator. The PI will recruit patients at the Headache Clinic. The patients are escorted to the Clinical Trials Unit (CTU) at Bayview where the therapy its provided and will be asked to fill out a questionnaire on pain, nausea, sound and light sensitivity using a visual analog score (VAS) for each symptom on a scale of 1-10. The patients will be randomized to either humidified oxygen, dry air, humidified air or dry oxygen. Patients will be asked to submit readings at the end of therapy, at 2 hours and 24 hours post-therapy. Treatment failure is defined as persistent headache despite treatment with oxygen or air. Participants will be removed from the trial if participants prematurely terminate therapy.
The investigators believe that using a sample size of 45 patients in each arm, the investigators will be able to show a statistically significant difference of >2 point change in the VAS pain score reduction between the two treatment groups with a confidence of 80%. No risk were reported in prior studies involving >100 patients and >500 episodes of treatment with air or oxygen. Because of the (at least 2 and 1/2 hour) delay in initiating standard of care treatments, subjects may experience a longer duration and/or intensity of pain from the headache than if standards of care was started as usual, i.e., sooner. Participants will be reimbursed for participation in this study which will compensate travel and parking.
Humidified oxygen, Dry oxygen, Humidified air, Dry air
Clinical Trials Unit, Johns Hopkins Bayview (JHU ICTR)
Johns Hopkins University
Published on BioPortfolio: 2019-10-23T13:11:56-0400
The purpose of this study is to compare heat and humidified oxygen with cold and dry oxygen in children with bronchiolitis. The hypotheses are that heating and humidifying inspired low fl...
Humidified Nasal High-flow with Oxygen (HNHF-O2) therapy has been reported to have acute beneficial effects in patients with hypoxemic respiratory failure who have been hospitalized. The u...
High Flow Heated and Humidified Nasal Oxygen therapy (HFNO) has been increasingly used in emergency medicine to assist patients with short term respiratory failure and to provide adequate ...
This purpose of this study is to determine whether nasal delivery of heated and humidified air for a period of 4 hours will improve the clearance of mucus from the lungs of patients with c...
Background: Patients undergoing awake brain surgery are exposed to non-humidified, non-warmed oxygen/air mix flow through a face mask for a prolonged duration. This causes increased discom...
To evaluate the necessity of oxygen humidification for low-flow oxygen therapy in children with Pierre-Robin syndrome.
Hypoxia is one of the most-frequent adverse events of sedated GI endoscopy, which can ultimately lead to serious consequences. No modalities have been previously found to totally prevent hypoxia. High...
Perioperative hypothermia may lead to serious complications. This study aims to investigate whether intraoperative insufflation of warmed and humidified carbon dioxide (W-H-CO) into the open wound dur...
Computational prediction of promising pyrazine and bipyridine analogues of a fluorinated MOF platform, MFN-Ni-L (M = SI/AL; N = SIX/FIVE; L = pyr/bipyr), for CO capture under pre-humidified conditions.
The CO2 separation performance has been explored under dry and pre-humidified conditions for the fluorinated metal organic frameworks SIFSIX-Ni-pyr, ALFFIVE-Ni-pyr, SIFSIX-Ni-bipyr and ALFFIVE-Ni-bipy...
The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)
A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtypes are common migraine (without aura) and classic migraine (with aura or neurological symptoms). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
Stable oxygen atoms that have the same atomic number as the element oxygen, but differ in atomic weight. O-17 and 18 are stable oxygen isotopes.
Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of signal transduction and gene expression, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS.
Unstable isotopes of oxygen that decay or disintegrate emitting radiation. O atoms with atomic weights 13, 14, 15, 19, and 20 are radioactive oxygen isotopes.
Neurology - Central Nervous System (CNS)
Alzheimer's Disease Anesthesia Anxiety Disorders Autism Bipolar Disorders Dementia Epilepsy Multiple Sclerosis (MS) Neurology Pain Parkinson's Disease Sleep Disorders Neurology is the branch of me...
Pain is a feeling (sharp or dull) triggered in the nervous system which can be transient or constant. Pain can be specific to one area of the body eg back, abdomen or chest or more general all over the body eg muscles ache from the flu. Without pain ...