Low Concentrate Detergents Versus Hypertonic Glucose for the Treatment of Telangiectasia
Summary
Using of low concentrate sodium tetradecyl sulfate for sclerotherapy of telangiectasias should be no less effective than hypertonic glucose, and have a comparable frequency of adverse events.
Description
For sclerotherapy of telangiectasias are used detergents. These are aggressive substances, which have a high frequency of adverse events. According to histological studies the safest concentration for the treatment of telangiectasias is less than that specified in the official instructions. The concentration of sodium tetradecyl sulfate 0.15% was effective and did not cause any adverse reactions in the treatment of telangiectasias from 0.8 to 1 mm in diameter. Small telangiectases (0.5 mm or less) require the treatment with the less aggressive sclerosing agent. Perhaps, the sodium tetradecyl sulfate 0.15%, 0.1% or even 0.05% and hypertonic glucose may be more effective and safe in this situation.
Study Design
Conditions
Sclerotherapy
Intervention
Sclerotherapy
Location
Bukina Oksana Vasilyevna
Tambov
Russian Federation
392014
Status
Not yet recruiting
Source
Derzhavin Tambov State University
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT04132323
- ClinicalTrials.gov processed this data on October 23, 2019
Published on BioPortfolio: 2019-10-24T12:49:36-0400
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Medical and Biotech [MESH] Definitions
Sclerotherapy
Treatment of varicose veins, hemorrhoids, gastric and esophageal varices, and peptic ulcer hemorrhage by injection or infusion of chemical agents which cause localized thrombosis and eventual fibrosis and obliteration of the vessels.
Portasystemic Shunt, Transjugular Intrahepatic
A type of surgical portasystemic shunt to reduce portal hypertension with associated complications of esophageal varices and ascites. It is performed percutaneously through the jugular vein and involves the creation of an intrahepatic shunt between the hepatic vein and portal vein. The channel is maintained by a metallic stent. The procedure can be performed in patients who have failed sclerotherapy and is an additional option to the surgical techniques of portocaval, mesocaval, and splenorenal shunts. It takes one to three hours to perform. (JAMA 1995;273(23):1824-30)
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