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The proposed randomized, double-blind research study will use functional magnetic resonance neuroimaging using state-of-the-art HCP acquisition protocols and analytic pipelines, to identify predictors and correlates of response to an accepted first-line pharmacological treatment for obsessive-compulsive disorder.
The proposed study intends to recruit 2 groups:
1. Matched healthy control participants will be imaged with one fMRI at baseline as a no-treatment comparison group; and
2. a randomized, double-blind group of unmedicated OCD participants who will be assigned to begin either immediate or placebo-delayed treatment, and who will be imaged with fMRIs at baseline and over the course of treatment with a selective serotonin reuptake inhibitor (SSRI), fluoxetine.
Hypothesis-driven analyses and exploratory analyses will be performed in parallel.
This study will address the following Specific Aims:
1. Identification of neural dysconnectivity associated with OCD symptomatology.
2. Characterizing neural markers of clinical response to SSRI pharmacotherapy.
3. Mapping neural predictors of clinical response to pharmacotherapy.
Fluoxetine - immediate treatment, Fluoxetine - delayed treatment
Yale OCD Research Clinic - CMHC/CNRU, 34 Park ST
Published on BioPortfolio: 2019-10-24T12:49:49-0400
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Mergers & Acquisitions
Commercial and market reports on mergers and acquisitions in the biotechnology, pharmaceutical, medical device and life-science industries. Mergers and acquisitions (abbreviated M&A;) is an aspect of corporate strategy, corporate finance and manageme...