Brain Network Changes Accompanying and Predicting Responses to Pharmacotherapy in OCD

2019-10-24 12:49:49 | BioPortfolio


The proposed randomized, double-blind research study will use functional magnetic resonance neuroimaging using state-of-the-art HCP acquisition protocols and analytic pipelines, to identify predictors and correlates of response to an accepted first-line pharmacological treatment for obsessive-compulsive disorder.


The proposed study intends to recruit 2 groups:

1. Matched healthy control participants will be imaged with one fMRI at baseline as a no-treatment comparison group; and

2. a randomized, double-blind group of unmedicated OCD participants who will be assigned to begin either immediate or placebo-delayed treatment, and who will be imaged with fMRIs at baseline and over the course of treatment with a selective serotonin reuptake inhibitor (SSRI), fluoxetine.

Hypothesis-driven analyses and exploratory analyses will be performed in parallel.

This study will address the following Specific Aims:

1. Identification of neural dysconnectivity associated with OCD symptomatology.

2. Characterizing neural markers of clinical response to SSRI pharmacotherapy.

3. Mapping neural predictors of clinical response to pharmacotherapy.

Study Design


Obsessive-Compulsive Disorder


Fluoxetine - immediate treatment, Fluoxetine - delayed treatment


Yale OCD Research Clinic - CMHC/CNRU, 34 Park ST
New Haven
United States




Yale University

Results (where available)

View Results


Published on BioPortfolio: 2019-10-24T12:49:49-0400

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