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Brain Network Changes Accompanying and Predicting Responses to Pharmacotherapy in OCD

2019-10-24 12:49:49 | BioPortfolio

Summary

The proposed randomized, double-blind research study will use functional magnetic resonance neuroimaging using state-of-the-art HCP acquisition protocols and analytic pipelines, to identify predictors and correlates of response to an accepted first-line pharmacological treatment for obsessive-compulsive disorder.

Description

The proposed study intends to recruit 2 groups:

1. Matched healthy control participants will be imaged with one fMRI at baseline as a no-treatment comparison group; and

2. a randomized, double-blind group of unmedicated OCD participants who will be assigned to begin either immediate or placebo-delayed treatment, and who will be imaged with fMRIs at baseline and over the course of treatment with a selective serotonin reuptake inhibitor (SSRI), fluoxetine.

Hypothesis-driven analyses and exploratory analyses will be performed in parallel.

This study will address the following Specific Aims:

1. Identification of neural dysconnectivity associated with OCD symptomatology.

2. Characterizing neural markers of clinical response to SSRI pharmacotherapy.

3. Mapping neural predictors of clinical response to pharmacotherapy.

Study Design

Conditions

Obsessive-Compulsive Disorder

Intervention

Fluoxetine - immediate treatment, Fluoxetine - delayed treatment

Location

Yale OCD Research Clinic - CMHC/CNRU, 34 Park ST
New Haven
Connecticut
United States
06519

Status

Recruiting

Source

Yale University

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-10-24T12:49:49-0400

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