HPV DNA Vaccine Via Electroporation for HPV16 Positive Cervical Neoplasia

2019-10-24 12:49:52 | BioPortfolio


The primary goal of this phase I open label study is to determine the safety and tolerability of pNGVL4aCRTE6E7L2 DNA vaccine, as administered by intramuscular (IM) injection with TriGrid™ electroporation to both HIV- or HIV+ adult female subjects (≥ 19 years), with biopsy confirmed cervical intraepithelial (CIN) II or III that is human papillomavirus (HPV) 16+.

Study Design


Human Papillomavirus Type 16




Johns Hopkins University
United States


Not yet recruiting


Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Results (where available)

View Results


Published on BioPortfolio: 2019-10-24T12:49:52-0400

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Medical and Biotech [MESH] Definitions

A type of human papillomavirus especially associated with malignant tumors of the genital and RESPIRATORY MUCOSA.

Vaccines or candidate vaccines used to prevent PAPILLOMAVIRUS INFECTIONS. Human vaccines are intended to reduce the incidence of UTERINE CERVICAL NEOPLASMS, so they are sometimes considered a type of CANCER VACCINES. They are often composed of CAPSID PROTEINS, especially L1 protein, from various types of ALPHAPAPILLOMAVIRUS.

A type of ALPHAPAPILLOMAVIRUS associated with high risk for anogenital neoplasms.


A type of ALPHAPAPILLOMAVIRUS especially associated with malignant tumors of the CERVIX and the RESPIRATORY MUCOSA.

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