Circuit-Based Approach to Suicide: Biomarkers, Predictors, and Novel Therapeutics

2019-10-24 12:49:54 | BioPortfolio


This neuroimaging study is a clinical trial investigating the effectiveness of intermittent theta-burst transcranial magnetic stimulation (iTBS-TMS) to the inferior parietal lobule (IPL) in reducing suicide risk in patients with major depressive disorder (MDD) and borderline personality disorder (BPD).


This neuroimaging study aims to determine the effectiveness of iTBS-TMS to the IPL in reducing suicide risk in patients with MDD and BPD. This study also aims to identify the structural and functional circuit properties that characterized the suicidal brain and the signatures that explain the clinical severity of suicidal risk. Moreover, this study aims to determine biological and dimensional predictors of anti-suicidal response to iTBS-TMS and its mechanism of action.

Study Design


Major Depressive Disorder


Intermittent Theta Burst Transcranial Magnetic Stimulation (Active), Intermittent Theta Burst Transcranial Magnetic Stimulation (Sham)


Massachusetts General Hospital
United States


Not yet recruiting


Massachusetts General Hospital

Results (where available)

View Results


Published on BioPortfolio: 2019-10-24T12:49:54-0400

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