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A Study To Determine The Safety, Tolerability, Skin Irritation Potential, And PK Following Topical Application Of PF-07038124 In Healthy Participants

2019-10-28 13:57:16 | BioPortfolio

Summary

The purpose of this study is to evaluate the skin irritation potential of PF-07038124 ointment and vehicle (placebo) in Part A following multiple-doses applied topically to healthy participants. In Part B, the safety, tolerability, pharmacokinetic (PK), and skin irritation potential of PF-07038124 will be evaluated. In Part A, the highest concentration of 0.06% PF-07038124 will be applied to normal skin with a small surface area of 20 cm2 (0.1% body surface area [BSA]), while Part B will evaluate application of PF-07038124 and vehicle (placebo) to a surface area of 2000 cm2 (10% BSA) and 4000 cm2 (20% BSA). These data will provide support for clinical development in participants with mild to moderate AD.

Study Design

Conditions

Dermatitis Atopic

Intervention

PF-07038124 and Vehicle, PF-07038124 or vehicle, PF-07038124 or vehicle, PF-07038124 or vehicle, PF-07038124 or vehicle, PF-07038124 or vehicle, PF-07038124 or vehicle

Location

PCRU
New Haven
Connecticut
United States
06511

Status

Not yet recruiting

Source

Pfizer

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-10-28T13:57:16-0400

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