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CD Patients Immune Status Evaluation

2019-10-28 13:57:16 | BioPortfolio

Summary

Using single cell sequencing method to evaluate and compare the immune status of patients with severe CD.

Study Design

Conditions

Severe Crohn's Diease

Intervention

colonic tissue biopsy

Status

Not yet recruiting

Source

First Affiliated Hospital of Zhejiang University

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-10-28T13:57:16-0400

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Medical and Biotech [MESH] Definitions

A subtype of MICROSCOPIC COLITIS, characterized by chronic watery DIARRHEA of unknown origin, a normal COLONOSCOPY but abnormal histopathology on BIOPSY. Microscopic examination of biopsy samples taken from the COLON show infiltration of LYMPHOCYTES in the superficial EPITHELIUM and the underlying connective tissue (lamina propria).

Inflammation of the COLONIC DIVERTICULA, generally with abscess formation and subsequent perforation.

A complex systemic syndrome with inflammatory and autoimmune components that affect the skin, fascia, muscle, nerve, blood vessels, lung, and heart. Diagnostic features generally include EOSINOPHILIA, myalgia severe enough to limit usual activities of daily living, and the absence of coexisting infectious, autoimmune or other conditions that may induce eosinophilia. Biopsy of affected tissue reveals a microangiopathy associated with diffuse inflammation involving connective tissue. (From Spitzer et al., J Rheumatol Suppl 1996 Oct;46:73-9; Blackburn WD, Semin Arthritis Rheum 1997 Jun;26(6):788-93)

Conducting a biopsy procedure with the aid of a MEDICAL IMAGING modality.

Removal and examination of tissue obtained through a transdermal needle inserted into the specific region, organ, or tissue being analyzed.

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DNA sequencing
DNA sequencing is the process of determining the precise order of nucleotides within a DNA molecule. During DNA sequencing, the bases of a small fragment of DNA are sequentially identified from signals emitted as each fragment is re-synthesized from a ...

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Crohn’s disease (CD) is a long-term condition that causes inflammation of the lining of the digestive system.  Inflammation can affect any part of the digestive system, from the mouth to the back passage, but most commonly occurs in the last s...


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