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A Prospective Study of Human Bone Adaptation Using a Novel in Vivo Loading Model

2019-10-28 13:57:18 | BioPortfolio

Summary

The purpose of this study is to understand how different types of mechanical forces can influence bone adaptation (and make bones stronger, potentially). Forces acting on bones cause mechanical strain. In small animals, strain magnitude and rate have been shown to stimulate bone adaptation. This study is designed to test the degree to which strain magnitude and rate govern bone adaptation in healthy adult women.

Description

The study consists of three Aims:

Aim 1: compare the effect on bone structure of mechanical signals with low strain magnitude, high strain magnitude, and control groups over a 12-month prospective period.

Aim 2. Compare the effect on bone structure of mechanical signals with low strain rate, high strain rate, and control groups over a 12-month prospective period.

Aim 3: Examine the effect of withdrawing mechanical signals, by measuring bone structure during the 12 months after the intervention is withdrawn.

The intervention is a voluntary forearm compression task, consisting of leaning onto the palm of the hand to produce a target force.

The primary outcome measure is change in distal radius bone mineral content (BMC).

Study Design

Conditions

Bone Loss

Intervention

voluntary forearm loading task

Status

Completed

Source

Worcester Polytechnic Institute

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-10-28T13:57:18-0400

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Medical and Biotech [MESH] Definitions

The inner and longer bone of the FOREARM.

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